81535-84-4

Basic information

• Product Name: 2-Butyn-1-one, 4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-1-phenyl-
• CAS NO: 81535-84-4
• Molecular Formula: C16H22O2Si
• Molecular Weight: 274.435
• Mol File: 81535-84-4.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: 2-Butyn-1-one, 4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-1-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Butyn-1-one, 4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-1-phenyl-(81535-84-4)
• EPA Substance Registry System: 2-Butyn-1-one, 4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-1-phenyl-(81535-84-4)

Safety Data

• Hazardous Substances Data: 81535-84-4(Hazardous Substances Data)

Upstream product

• 81535-79-7 tert-butyl-dimethyl(3-(tributylstannanyl)prop-2-yn-1-yl)oxysilane 
• 98-88-4 benzoyl chloride 
• 76782-82-6 tert-Butyldimethyl(prop-2-ynyloxy)silane 
• 6919-61-5 N-methoxy-N-methylbenzamide 
• 136590-95-9 [4-(tert-Butyl-dimethyl-silanyloxy)-1-trimethylsilanyloxy-but-2-ynyl]-benzene 

Downstream Products

• 1360896-22-5 (E)-4-(tert-butyldimethylsilyl)oxy-2-dimethyl(phenyl)silyl-1-phenyl-2-buten-1-one 
• 1207382-05-5 C₁₈H₂₈O₂S₂Si 
• 1207382-10-2 C₁₉H₃₀O₂S₂Si 
• 143878-47-1 4-{[tert-butyl(dimethyl)silyl]oxy}-1-phenylbutan-1-one 

Relevant articles and documents

INHIBITORS OF HISTONE DEACETYLASE

ABSTRACT OF THE DISCLOSURE This invention relates to compounds and methods for the inhibition of HDAC enzymatic activity. More particularly, the invention provides for compounds of formula (I), (I) and N-oxides, hydrates, solvates, pharmaceutically acceptable salts, prodrugs and complexes thereof, and racemic and scalemic mixtures, diastereomers and enantiomers thereof, wherein L, M, n, R, W, X and Y are as defined in the specification.

Room temperature palladium catalysed coupling of acyl chlorides with terminal alkynes

Conditions are reported for the facile, high-yielding coupling of acyl chlorides with terminal alkynes in a reaction involving palladium and copper iodide; the reaction is tolerant of a wide variety of acyl chlorides and terminal alkynes and provides a co

Highly stereoselective addition of stannylcuprates to alkynones

The addition of stannylcuprate reagents such as (Bu3Sn)(PhS)CuLi to alkynones has been found to proceed in high yield and with excellent stereoselectivity for the Z isomer of the product (>95%). The behavior of the stannylcuprates is thus very different from that of their "carbocuprate" counterparts such as Me2CuLi or Me2Cu(CN)Li2 which are nonstereoselective. Furthermore, in contrast to the reactions of (R3Sn)(PhS)CuLi with the corresponding alkynoates, the presence of a proton source in the reaction medium has no effect on the stereoselectivity of the reaction of alkynones.