81729-45-5Relevant articles and documents
6π-Electrocyclization in water: microwave-assisted synthesis of polyheterocyclic-fused quinoline-2-thiones
Chen, Xiao-Lan,Li, Xiao-Yun,Liang, Xing-Xing,Liu, Yan,Lu, Xin-Yuan,Qu, Ling-Bo,Wei, Chuan-Wan,Yu, Bing,Zhu, Shan-Shan
supporting information, p. 4445 - 4449 (2020/08/10)
Microwave-assisted synthesis of polyheterocyclic-fused quinoline-2-thiones through the annulation of ortho-heteroaryl anilines and CS2 was realized in water without using any catalysts and additives. The desired products were obtained in high yields throu
First enantioselective synthesis of aptazepine
Roszkowski, Piotr,Maurin, Jan K.,Czarnocki, Zbigniew
experimental part, p. 241 - 246 (2012/03/26)
Aptazepine (2-methyl-1,3,4,14b-tetrahydro-2H,10H-pyrazino[1,2-a]pyrrolo[2, 1-c][1,4]benzodiazepine), a potent tetracyclic antidepressant, was synthesized in both its enantiopure forms by using an asymmetric transfer hydrogenation in a key step. Reduction of the prochiral imine 7 gave the products (R)- and (S)-8 in 63% and 61% ee, respectively, but a single crystallization improved the enantiomeric purity to 98% ee. The final (R)- and (S)-aptazepines were prepared in four subsequent steps. The absolute configuration of intermediate (S)-8 was determined by X-ray crystallography. Georg Thieme Verlag Stuttgart · New York.
Decarboxylative formation of N-alkyl pyrroles from 4-hydroxyproline
Deb, Indubhusan,Coiro, Daniel J.,Seidel, Daniel
scheme or table, p. 6473 - 6475 (2011/06/28)
N-Alkyl pyrroles are obtained in a single step from 4-hydroxyproline and aldehydes in just 15 min under microwave irradiation.