82110-17-6Relevant articles and documents
Utilizing on- and off-line monitoring tools to follow a kinetic resolution step during flow synthesis
Farley, Kathleen A.,Reilly, Usa,Anderson, Dennis P.,Boscoe, Brian P.,Bundesmann, Mark W.,Foley, David A.,Lall, Manjinder S.,Li, Chao,Reese, Matthew R.,Yan, Jiangli
, p. 348 - 354 (2017)
In situ reaction monitoring tools offer the ability to track the progress of a synthetic reaction in real time to facilitate reaction optimization and provide kinetic/mechanistic insight. Herein, we report the utilization of flow NMR, flow IR, and other off-line spectroscopy tools to monitor the progress of a flow chemistry reaction. The on-line and off-line tools were selected to facilitate the stereoselective kinetic resolution of a key racemic monomer, which lacked a chromophore, making conventional reaction monitoring difficult. Copyright
NOVEL IMIDAZO[4,5-C]QUINOLINE DERIVATIVES AS LRRK2 INHIBITORS
-
Page/Page column 53; 54; 55, (2018/09/28)
The present invention provides novel imidazo[4,5-c]quinoline derivatives of Formula (I), and the pharmaceutically acceptable salts thereof I wherein R1, R2 and R3 are as defined in the specification. The invention is also directed to pharmaceutical compositions comprising the compounds of Formula I and to use of the compounds in the treatment of diseases associated with LRRK2, such as neurodegenerative diseases including Parkinson's disease or Alzheimer's disease, cancer, Crohn's disease or leprosy.
4-Methoxy-2-methyltetrahydropyrans: Chiral Leukotriene Biosynthesis Inhibitors, Related to ICI D2138, Which Display Enantioselectivity
Crawley, Graham C.,Briggs, Malcolm T.,Dowell, Robert I.,Edwards, Philip N.,Hamilton, Patricia M.,et al.
, p. 295 - 296 (2007/10/02)
-
