823809-32-1

Basic information

• Product Name: Benzene, 1-[(1E)-2-(4-methylphenyl)ethenyl]-2-nitro-
• CAS NO: 823809-32-1
• Molecular Formula: C15H13NO2
• Molecular Weight: 239.274
• Mol File: 823809-32-1.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: Benzene, 1-[(1E)-2-(4-methylphenyl)ethenyl]-2-nitro-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 1-[(1E)-2-(4-methylphenyl)ethenyl]-2-nitro-(823809-32-1)
• EPA Substance Registry System: Benzene, 1-[(1E)-2-(4-methylphenyl)ethenyl]-2-nitro-(823809-32-1)

Safety Data

• Hazardous Substances Data: 823809-32-1(Hazardous Substances Data)

Upstream product

• 577-19-5 2-nitrophenyl bromide 
• 72316-17-7 (E)-2-(4-methylphenyl)ethenylboronic acid 
• 104-82-5 4-Methylbenzyl chloride 
• 1530-37-6 (4-methylbenzyl)triphenylphosphonium chloride 
• 552-89-6 2-nitro-benzaldehyde 
• 2378-86-1 4-methylbenzyltriphenylphosphonium bromide 
• 622-97-9 1-ethenyl-4-methylbenzene 
• 15163-59-4 potassium o-nitrobenzoate 

Downstream Products

• 860543-84-6 3-(4'-methylphenyl)-3-hydroxy-1,3-dihydro-indol-2-one 
• 823809-36-5 trans-N-{2-[2-(4-methylphenyl)ethenyl]phenyl}aminoacetic acid 
• 823809-34-3 N-(2-aminobenzylidene)-4-methylaniline 
• 55577-25-8 2-(4-methylphenyl)-1H-indole 

Relevant articles and documents

Counterion Control of t-BuO-Mediated Single Electron Transfer to Nitrostilbenes to Construct N-Hydroxyindoles or Oxindoles

tert-Butoxide unlocks new reactivity patterns embedded in nitroarenes. Exposure of nitrostilbenes to sodium tert-butoxide was found to produce N-hydroxyindoles at room temperature without an additive. Changing the counterion to potassium changed the reaction outcome to yield solely oxindoles through an unprecedented dioxygen-transfer reaction followed by a 1,2-phenyl migration. Mechanistic experiments established that these reactions proceed via radical intermediates and suggest that counterion coordination controls whether an oxindole or N-hydroxyindole product is formed.

Styrylphenylphthalimides as Novel Transrepression-Selective Liver X Receptor (LXR) Modulators

Anti-inflammatory effects of liver X receptor (LXR) ligands are thought to be largely due to LXR-mediated transrepression, whereas side effects are caused by activation of LXR-responsive gene expression (transactivation). Therefore, selective LXR modulators that preferentially exhibit transrepression activity should exhibit anti-inflammatory properties with fewer side effects. Here, we synthesized a series of styrylphenylphthalimide analogues and evaluated their structure-activity relationships focusing on LXRs-transactivating-agonistic/antagonistic activities and transrepressional activity. Among the compounds examined, 17l showed potent LXR-transrepressional activity with high selectivity over transactivating activity and did not show characteristic side effects of LXR-transactivating agonists in cells. This representative compound, 17l, was confirmed to have LXR-dependent transrepressional activity and to bind directly to LXRβ. Compound 17l should be useful not only as a chemical tool for studying the biological functions of LXRs transrepression but also as a candidate for a safer agent to treat inflammatory diseases.

Complete 1H and 13C NMR spectral assignment of cis- and trans- 3-{2-[2-(4-methylphenyl)ethenyl]phenyl}sydnones

1H and 13C NMR spectra of cis- and trans-3-{2-[2-(4-methylphenyl)ethenyl]phenyl]}sydnones, the first stilbene-substituted mezoionic oxadiazolium rings, were fully assigned combining the information in various solvents, such as deuter