824-40-8Relevant articles and documents
From Pyridine- N-oxides to 2-Functionalized Pyridines through Pyridyl Phosphonium Salts: An Umpolung Strategy
Bugaenko, Dmitry I.,Yurovskaya, Marina A.,Karchava, Alexander V.
supporting information, p. 6099 - 6104 (2021/08/03)
The reactions of pyridine-N-oxides with Ph3P under the developed conditions provide an unprecedented route to (pyridine-2-yl)phosphonium salts. Upon activation with DABCO, these salts readily serve as functionalized 2-pyridyl nucleophile equivalents. This umpolung strategy allows for the selective C2 functionalization of the pyridine ring with electrophiles, avoiding the generation and use of unstable organometallic reagents. The protocol operates at ambient temperature and tolerates sensitive functional groups, enabling the synthesis of otherwise challenging compounds.
ANTIBACTERIAL THERAPEUTICS AND PROPHYLACTICS
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Paragraph 00332; 00369; 00373; 00387, (2017/02/24)
The present disclosure relates generally to novel molecules, compositions, and formulations for treatment of bacterial infections in general and more specifically to bacterial infections with antibiotic resistant pathogens.
Co(ii), a catalyst for selective conversion of phenyl rings to carboxylic acid groups
Sinha, Shashi Bhushan,Campos, Jess,Brudvig, Gary W.,Crabtree, Robert H.
, p. 49395 - 49399 (2014/12/10)
An inexpensive protocol for the conversion of -C6H4R into -COOH groups using Co(ii)-Oxone mixture as the catalytic system is described. A series of substrates containing substituted and non-substituted phenyl groups could be selectively converted into carboxylic acids. Initial mechanistic data have been provided.