827-66-7

Basic information

• Product Name: N-Acetyl2-bromo-5-chloroaniline
• Synonyms: N-Acetyl2-bromo-5-chloroaniline
• CAS NO: 827-66-7
• Molecular Formula: C₈H₇BrClNO
• Molecular Weight: 248.506
• Mol File: 827-66-7.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-Acetyl2-bromo-5-chloroaniline(CAS DataBase Reference)
• NIST Chemistry Reference: N-Acetyl2-bromo-5-chloroaniline(827-66-7)
• EPA Substance Registry System: N-Acetyl2-bromo-5-chloroaniline(827-66-7)

Safety Data

• Hazardous Substances Data: 827-66-7(Hazardous Substances Data)

Usage

General Description

N-Acetyl2-bromo-5-chloroaniline is a chemical compound with the molecular formula C8H7BrClNO. It is a derivative of aniline, containing both acetyl, bromine, and chlorine functional groups. N-Acetyl2-bromo-5-chloroaniline is commonly used as an intermediate in the synthesis of pharmaceuticals and dyes. It is a white to off-white solid at room temperature and is moderately soluble in water. N-Acetyl2-bromo-5-chloroaniline may have potential uses in various chemical and industrial processes. However, it is important to handle this compound with care due to its potentially hazardous properties.

Upstream product

• 614-76-6 N-acetyl-2-bromoaniline 
• 823-57-4 2-bromo-5-chloroaniline 
• 75-36-5 acetyl chloride 
• 41513-04-6 2-chloro-5-bromonitrobenzene 

Downstream Products

• 1006-99-1 2-methyl-5-chloro-benzothiazole 
• 708-73-6 7-chloro-2-methyl-4H-3,1-benzoxazin-4-one 
• 126759-61-3 1-(6-chloroindol-1-yl)ethanone 
• 126759-55-5 2-ethenyl-5-chloroacetanilide 

Relevant articles and documents

Pd-Catalyzed Carbonylative Synthesis of 4H-Benzo[d][1,3]Oxazin-4-Ones Using Benzene-1,3,5-Triyl Triformate as the CO Source

A facile synthesis of 4H-benzo[d][1,3]oxazin-4-one derivatives by Pd-catalyzed carbonylative cross-coupling between N-(ortho-bromoaryl)amides and benzene-1,3,5-triyl triformate (TFBen) was developed. This procedure does not require the toxic and flammable gas CO as the carbonyl source and tolerates a wide scope of functional groups. Remarkably, 4H-benzo[d][1,3]oxazin-4-ones incorporated to natural products and drugs can be constructed by this method.

PYRIMIDINONE DERIVATIVE HAVING AUTOTAXIN-INHIBITORY ACTIVITY

A compound according to any one of formula (Ia) to (Ic), or its pharmaceutically acceptable salt: wherein R1, R2, R3, R4a, R4c, R5 are as defined in the description.