82923-76-0

Basic information

• Product Name: S)-(-)-Indoline-2-carboxylic acid hydrochloride
• Synonyms: S)-(-)-Indoline-2-carboxylic acid hydrochloride
• CAS NO: 82923-76-0
• Molecular Formula: C₉H₉NO₂*ClH
• Molecular Weight: 199.63
• Mol File: 82923-76-0.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: S)-(-)-Indoline-2-carboxylic acid hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: S)-(-)-Indoline-2-carboxylic acid hydrochloride(82923-76-0)
• EPA Substance Registry System: S)-(-)-Indoline-2-carboxylic acid hydrochloride(82923-76-0)

Safety Data

• Hazardous Substances Data: 82923-76-0(Hazardous Substances Data)

Upstream product

• 79815-20-6 (S)-indoline-2-carboxylic acid 
• 82923-75-9 N-acetyl-(S)-2,3-dihydro-1H-indole-2-carboxylic acid 
• 10441-26-6 N-acetyl-indole-2-carboxylic acid 
• 1477-50-5 Indole-2-carboxylic acid 
• 82950-72-9 1-acetyl-2,3-indoline-2-carboxylic acid 

Downstream Products

• 82923-95-3 (S)-1-(4-Carboxy-2-methyl-pentanoyl)-2,3-dihydro-1H-indole-2-carboxylic acid 
• 141410-06-2 (S)-indoline-2-carboxylic acid methyl ester 
• 82924-03-6 1-<(2R,4R)-4-(ethoxycarbonyl)-2,4-dimethylbutyryl>indoline-2(S)-carboxylic acid 
• 97975-44-5 1-indoline-2(S)-carboxylic acid 
• 97975-39-8 1-(N-carbobenzoxy-N-benzyl-γ-D-glutamyl)indoline-2(S)-carboxylic acid 
• 97975-37-6 1-[N-(p-tolylsulfonyl)-γ-D-glutamyl]indoline-2(S)-carboxylic acid 
• 97975-54-7 1-[4-(N-carbobenzoxyamino)-4-ethoxycarbonyl-4(R)-butyryl]indoline-2(S)-carboxylic acid 
• 97975-38-7 1-[N-(benzylsulfonyl)-γ-D-glutamyl]indoline-2(S)-carboxylic acid 
• 97975-34-3 1-(N-carbophenethyl-γ-D-glutamyl)indoline-2(S)-carboxylic acid 
• 97975-36-5 1-[N-(phenylcarbamoyl)-γ-D-glutamyl]indoline-2(S)-carboxylic acid 
• 97975-35-4 (S)-1-(N-benzoyl-γ-D-glutamyl)-2,3-dihydro-1H-indole-2-carboxylic acid 
• 97975-42-3 1-(N-benzyl-γ-D-glutamyl)indoline-2(S)-carboxylic acid 
• 97975-53-6 ethyl 1-<4-(N-carbobenzoxyamino)-4-carboethoxy-4(R)-butyryl>indoline-2(S)-carboxylic acid 
• 97975-32-1 (S)-1-((S)-4-Benzyloxycarbonylamino-4-carboxy-butyryl)-2,3-dihydro-1H-indole-2-carboxylic acid 

Relevant articles and documents

Process for the preparation of enantiomerically enriched indoline-2-carboxylic acid

The present invention relates to a process for the preparation of an enantiomerically enriched optionally substituted indoline-2-carboxylic acid or a salt thereof, said process comprising subjecting an enantiomerically enriched chiral 2-amino-3-(2-X-substituted aryl)-propionic acid or 2-yl-substituted-amino -3-(2-X-substituted aryl)-propionic acid or a salt thereof, wherein X is a leaving group, to cyclisation, preferably at a temperature of below about 140°C, and in case of the yl-substituted compound, removing said yl-substituent by hydrolysis either prior to or after said cyclisation.

1-mercaptoalkanoylindoline-2-carboxylic acids

1-Mercaptoalkanoylindoline-2-carboxylic acids, e.g., those of the formula STR1 and functional derivatives thereof, are antihypertensive and cardioactive agents.

1-CARBOXYALKANOYLINDOLINE-2-CARBOXYLIC ACIDS

1-Carboxy-(alkanoyl or aralkanoyl)-indoline-2-carboxylic acids, e.g., those of the formula STR1 R=H, alkyl, alkoxy, halogeno or CF. sub.3 ; R'=H or R-phenyl;m=0 or 1;p, q=0 to 2; and functional derivatives thereof, are antihypertensive a