84271-78-3

Basic information

• Product Name: SATP
• Synonyms: N-SUCCINIMIDYL 3-(ACETYLTHIO)PROPIONATE;N-SUCCINIMIDYL-S-ACETYLTHIOPROPIONATE;S-ACETYL-3-MERCAPTOPROPIONIC ACID-N-HYDROXYSUCCINIMIDE ESTER;SATP;3-ACETYLSULFANYL-PROPIONIC ACID-OSU;3-(acetylthio)propionic acid n-succinimidyl ester;Acetic 2-(2,5-dioxopyrrolidin-1-yl)propanoic thioanhydride;N-Succinimidyl 3-(acetylthio)propionate, SATP
• CAS NO: 84271-78-3
• Molecular Formula: C₉H₁₁NO₅S
• Molecular Weight: 245.25
• Product Categories: MTS and Sulfhydryl Active Reagents;MTS & Sulfhydryl Active Reagents;Heterocycles
• Mol File: 84271-78-3.mol
• Article Data: 3

Chemical Properties

• Melting Point: 48-50°C
• Boiling Point: 366.1°C at 760 mmHg
• Flash Point: 175.2°C
• Appearance: /
• Density: 1.4g/cm³
• Vapor Pressure: 1.49E-05mmHg at 25°C
• Refractive Index: 1.553
• Storage Temp.: −20°C
• Solubility: Chloroform, Ethyl Acetate
• BRN: 5562810
• CAS DataBase Reference: SATP(CAS DataBase Reference)
• NIST Chemistry Reference: SATP(84271-78-3)
• EPA Substance Registry System: SATP(84271-78-3)

Safety Data

• WGK Germany: 3
• F: 1-3-10
• Hazardous Substances Data: 84271-78-3(Hazardous Substances Data)

Usage

Description

SATP, or 3-(Acetylthio)propionic acid N-succinimidyl ester, is a beige solid that is used for tip functionalization and surface modification of antibodies on atomic force microscope tips. It is also used in the synthesis of oligosaccharides and for binding antibodies and ligands to atomic force microscope tips.

Uses

Used in Oligosaccharide Synthesis:
SATP is used as a reagent in the synthesis of oligosaccharides, which are short chains of monosaccharides linked by glycosidic bonds. These oligosaccharides have various biological functions and are important in fields such as pharmaceuticals, food, and cosmetics.
Used in Atomic Force Microscopy:
SATP is used for tip functionalization and surface modification of antibodies on atomic force microscope tips. This allows for the study of molecular interactions and the structural properties of biological molecules at the nanoscale.
Used in Binding Antibodies and Ligands:
SATP is used for binding antibodies and ligands to atomic force microscope tips, enabling the investigation of molecular recognition and binding events with high spatial resolution. This technique is useful in fields such as drug discovery, diagnostics, and materials science.

InChI:InChI=1/C9H11NO5S/c1-6(11)16-5-4-9(14)15-10-7(12)2-3-8(10)13/h2-5H2,1H3

Upstream product

• 6066-82-6 1-hydroxy-pyrrolidine-2,5-dione 
• 41345-70-4 3-acetylsulfanyl-propionic acid 

Downstream Products

• 97185-83-6 N-(3-Acetylthiopropionyl)-L-phenylalanine 

Relevant articles and documents

Development of enzymatically cleavable prodrugs derived from dendritic polyglycerol

In this Letter we report the synthesis and in vitro studies of cleavable polymer-drug conjugates derived from dendritic polyglycerol and maleimide-bearing prodrugs of doxorubicin and methotrexate that are cleaved by cathepsin B. Cleavage properties and cytotoxicity of the new conjugates are presented.

Hydrophobic effects on rates and substrate selectivities in polymeric transaminase mimics

The amination of ketoacids to amino acids by pyridoxamine is greatly accelerated when the pyridoxamine is covalently linked to polyethylenimine carrying N-methyl and N-lauryl groups. Michaelis-Menten kinetics is seen with all substrates, from which the effect of the lauryl groups and the methyl groups can be determined with respect to the strength of binding of the substrate and the rate constant k2 within the complex. The polyamine catalyzes the reaction using acid and base groups, the lauryl groups increase k2 by producing a nonpolar medium in which the reaction occurs, and the lauryl groups promote binding of hydrophobic substrates. The result is that the amination of indolepyruvic acid to produce tryptophan is accelerated by 240000-fold. Copyright