84459-83-6

Basic information

• Product Name: potassium 2-(4-nitrobenzoyl)hydrazinecarbodithioate
• Synonyms: potassium 2-(4-nitrobenzoyl)hydrazinecarbodithioate
• CAS NO: 84459-83-6
• Molecular Weight: 295.384
• Mol File: 84459-83-6.mol
• Article Data: 22

Chemical Properties

• CAS DataBase Reference: potassium 2-(4-nitrobenzoyl)hydrazinecarbodithioate(CAS DataBase Reference)
• NIST Chemistry Reference: potassium 2-(4-nitrobenzoyl)hydrazinecarbodithioate(84459-83-6)
• EPA Substance Registry System: potassium 2-(4-nitrobenzoyl)hydrazinecarbodithioate(84459-83-6)

Safety Data

• Hazardous Substances Data: 84459-83-6(Hazardous Substances Data)

Upstream product

• 122-04-3 4-nitro-benzoyl chloride 
• 62-23-7 4-nitro-benzoic acid 
• 619-50-1 4-nitrobenzoic acid methyl ester 
• 99-77-4 ethyl 4-nitrobenzoate 
• 75-15-0 carbon disulfide 
• 636-97-5 N-amino-(4-nitrophenyl)carboxamide 

Downstream Products

• 1349193-03-8 C₁₄H₁₁N₅O₂S 
• 81188-34-3 5-(p-nitrophenyl)-2-mercapto-1,3,4-thiadiazole 
• 23766-30-5 5-(4-nitrophenyl)-1,3,4-oxadiazole-2(3H)-thione 
• 1578155-51-7 N-(3-chloro-4-fluorophenyl)-5-methyl-6-(3-(4-nitrophenyl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazol-6-yl)selenopheno[2,3-d]pyrimidin-4-amine 
• 1578155-40-4 N-(4-chlorophenyl)-5-methyl-6-(3-(4-nitrophenyl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazol-6-yl)selenopheno[2,3-d]pyrimidin-4-amine 
• 84474-29-3 2,6-Dimethyl-1-{4-[5-(4-nitro-phenyl)-[1,3,4]thiadiazol-2-ylsulfanyl]-but-2-ynyl}-piperidine 
• 84459-79-0 1-Methyl-4-{4-[5-(4-nitro-phenyl)-[1,3,4]thiadiazol-2-ylsulfanyl]-but-2-ynyl}-piperazine 
• 84459-72-3 1-{4-[5-(4-Nitro-phenyl)-[1,3,4]thiadiazol-2-ylsulfanyl]-but-2-ynyl}-azocane 
• 84459-80-3 4-{4-[5-(4-Nitro-phenyl)-[1,3,4]thiadiazol-2-ylsulfanyl]-but-2-ynyl}-morpholine 
• 84459-71-2 1-{4-[5-(4-Nitro-phenyl)-[1,3,4]thiadiazol-2-ylsulfanyl]-but-2-ynyl}-azepane 
• 84459-70-1 2-Methyl-1-{4-[5-(4-nitro-phenyl)-[1,3,4]thiadiazol-2-ylsulfanyl]-but-2-ynyl}-piperidine 

Relevant articles and documents

Design, synthesis, antibacterial evaluation, and computational studies of hybrid oxothiazolidin–1,2,4-triazole scaffolds

Bacterial infections are a serious threat to human health due to the development of resistance against the presently used antibiotics. The problem of growing and widespread antibiotic resistance is only getting worse with the shortage of new classes of antibiotics, creating a substantial unmet medical need in the treatment of serious bacterial infections. Therefore, in the present work, we report 18 novel hybrid thiazolidine–1,2,4-triazole derivatives as DNA gyrase inhibitors. The derivatives were synthesized by multistep organic synthesis and characterized by spectroscopic methods (1H and 13C nuclear magnetic resonance and mass spectroscopy). The derivatives were tested for DNA gyrase inhibition, and the result emphasized that the synthesized derivatives have a tendency to inhibit the function of DNA gyrase. Furthermore, the compounds were also tested for antibacterial activity against three Gram-positive (Bacillus subtilis [NCIM 2063], Bacillus cereus [NCIM 2156], Staphylococcus aureus [NCIM 2079]) and two Gram-negative (Escherichia coli [NCIM 2065], Proteus vulgaris [NCIM 2027]) bacteria. The derivatives showed a significant-to-moderate antibacterial activity with noticeable antibiofilm efficacy. Quantitative structure–activity relationship (QSAR), ADME (absorption, distribution, metabolism, elimination) calculation, molecular docking, radial distribution function, and 2D fingerprinting were also performed to elucidate fundamental structural fragments essential for their bioactivity. These studies suggest that the derivatives 10b and 10n have lead antibacterial properties with significant DNA gyrase inhibitory efficacy, and they can serve as a starting scaffold for the further development of new broad-spectrum antibacterial agents.

Efficient formation of C–S bond using heterocyclic thiones and arynes

Phenylthio heterocyclic compounds are widely used because of their diverse biological activities and medicinal prospects. Here, a facile method was reported. An arylation of 1,3,4-oxa(thia)diazol-2-thiones reacting with arynes to build C(aryl)-S bonds in the presence of CsF had good yields and excellent selectivity. The reaction was completed in short time without using expensive reagents and catalysts. Present reaction system is an efficient procedure to process phenylthio heterocyclic compounds and reveals a sustainable method and better application prospects in future organic synthesis.

Synthesis and antimicrobial activity of piperine analogues containing 1,2,4-triazole ring

A series 1,2,4-triazole piperine analogues (TP1-TP6) were designed and synthesized. The structures were confirmed using 1H NMR and 13C NMR. Antibacterial study was done using Gram-positive (Staphylococcus aureus and Bacillus cereus) and Gram-negative microorganisms (E. coli and Pseudomonas aeruginosa) by disc diffusion method. Compound containing chloro substitution (TP6) showed the highest effect, while compound TP1, TP3, TP4, TP5 showed the moderate activity.