845744-00-5

Basic information

• Product Name: ethyl 2-{[2-(1,3-dioxoisoindolin-2-yl)ethoxy]methyl}-4-(2-chlorophenyl)-5-cyano-6-methyl-1,4-dihydropyridine-3-carboxylate
• Synonyms: ethyl 2-{[2-(1,3-dioxoisoindolin-2-yl)ethoxy]methyl}-4-(2-chlorophenyl)-5-cyano-6-methyl-1,4-dihydropyridine-3-carboxylate
• CAS NO: 845744-00-5
• Molecular Weight: 505.958
• Mol File: 845744-00-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: ethyl 2-{[2-(1,3-dioxoisoindolin-2-yl)ethoxy]methyl}-4-(2-chlorophenyl)-5-cyano-6-methyl-1,4-dihydropyridine-3-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 2-{[2-(1,3-dioxoisoindolin-2-yl)ethoxy]methyl}-4-(2-chlorophenyl)-5-cyano-6-methyl-1,4-dihydropyridine-3-carboxylate(845744-00-5)
• EPA Substance Registry System: ethyl 2-{[2-(1,3-dioxoisoindolin-2-yl)ethoxy]methyl}-4-(2-chlorophenyl)-5-cyano-6-methyl-1,4-dihydropyridine-3-carboxylate(845744-00-5)

Safety Data

• Hazardous Substances Data: 845744-00-5(Hazardous Substances Data)

Upstream product

• 638-07-3 ethyl (2-chloroaceto)acetate 
• 3891-07-4 N-(2-Hydroxyethyl)phthalimide 
• 1118-61-2 3-Aminocrotononitrile 
• 89-98-5 2-chloro-benzaldehyde 
• 88150-75-8 ethyl 4-[2-(phthalimido)ethoxy]acetoacetate 

Downstream Products

• 845744-03-8 ethyl 4-(2-chlorophenyl)-5-cyano-2-({2-[2-(4-hydroxyphenoxy)acetylamino]ethoxy}methyl)-6-methyl-1,4-dihydropyridine-3-carboxylate 
• 845744-02-7 ethyl 4-(2-chlorophenyl)-5-cyano-6-methyl-2-[(2-{2-[4-(phenylmethoxy)phenoxy]acetylamino}ethoxy)methyl]-1,4-dihydropyridine-3-carboxylate 
• 845743-65-9 ethyl 2-({2-[2-(4-{(2S)-2-hydroxy-3-[(methylethyl)amino]propoxy}phenoxy)acetylamino]ethoxy}methyl)-4-(2-chlorophenyl)-5-cyano-6-metllyl-1,4-dihydropyridine-3-carboxylate 

Relevant articles and documents

COMPOUNDS WITH COMBINED CALCIUM CHANNEL BLOCKER AND β-ADRENERGIC ANTAGONIST OR PARTIAL AGONIST ACTIVITIES FOR TREATMENT OF HEART DISEASE

The present invention provides compounds possessing inhibitory activity against β-adrenergic receptors and L-type calcium channels. The present invention further provides pharmaceutical compositions comprising such compounds, methods of preparing such compounds, and methods of using such compounds for regulating calcium homeostasis, for treating a disease, disorder or condition in which disregulation of calcium homeostasis is implicated, and for treating hypertension, cardiovascular disease, congestive heart failure, myocardial ischemia, cardiomyopathies, stroke or epilepsy.