88150-75-8

Basic information

• Product Name: ETHYL4-[2-(1,3-DIOXO-1,3-DIHYDRO-2H-ISOINDOL-2-YL)ETHOXYL]-3-OXOBUTANOATE
• Synonyms: ETHYL4-[2-(1,3-DIOXO-1,3-DIHYDRO-2H-ISOINDOL-2-YL)ETHOXYL]-3-OXOBUTANOATE;Ethyl-4(2-Phthalimido Ethoxy)Acetoacetate;Butanoic acid,4-[2-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)ethoxy]-3-oxo-, ethyl ester;Ethyl 4-(2-(1,3-dioxoisoindolin-2-yl)ethoxy)-3-oxobutanoate;4-(2-PhthaliMidoethoxy)acetoacetic Acid Ethyl Ester;ETHYL-4-(2-(PHTHALIMIDO)ETHOXY)ACETOACET ATE (MEIS S.NO.1122 & COUNTRY GROUP B)
• CAS NO: 88150-75-8
• Molecular Formula: C₁₆H₁₇NO₆
• Molecular Weight: 319.31
• EINECS: 1308068-626-2
• Mol File: 88150-75-8.mol
• Article Data: 14

Chemical Properties

• Boiling Point: 479.7±30.0 °C(Predicted)
• Appearance: /
• Density: 1.297±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• Solubility: Chloroform (Slightly), DMSO (Sparingly), Methanol (Sparingly)
• PKA: 9.83±0.46(Predicted)
• CAS DataBase Reference: ETHYL4-[2-(1,3-DIOXO-1,3-DIHYDRO-2H-ISOINDOL-2-YL)ETHOXYL]-3-OXOBUTANOATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL4-[2-(1,3-DIOXO-1,3-DIHYDRO-2H-ISOINDOL-2-YL)ETHOXYL]-3-OXOBUTANOATE(88150-75-8)
• EPA Substance Registry System: ETHYL4-[2-(1,3-DIOXO-1,3-DIHYDRO-2H-ISOINDOL-2-YL)ETHOXYL]-3-OXOBUTANOATE(88150-75-8)

Safety Data

• Hazardous Substances Data: 88150-75-8(Hazardous Substances Data)

Usage

Uses

4-(2-Phthalimidoethoxy)acetoacetic Acid Ethyl Ester is an intermediate in the synthesis of Amlodipine Besilate (A633500) related compounds.

Upstream product

• 13176-46-0 4-bromoethyl acetoacetate 
• 1074-82-4 potassium phtalimide 
• 107-07-3 2-chloro-ethanol 
• 623-73-4 diazoacetic acid ethyl ester 
• 81142-14-5 [2-(1,3-dioxo-1,3-dihydroisoindol-2-yl)ethoxy]acetaldehyde 
• 85-44-9 phthalic anhydride 
• 3891-07-4 N-(2-Hydroxyethyl)phthalimide 
• 638-07-3 ethyl (2-chloroaceto)acetate 
• 6148-64-7 ethyl potassium malonate 
• 69676-65-9 2-(2-phthalimidoethoxy)-acetic acid 
• 69676-63-7 2-(2-phthalimidoethoxy)ethanol 

Downstream Products

• 103198-42-1 4-(2,3-Dichloro-phenyl)-2-[2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-ethoxymethyl]-6-methyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid diethyl ester 
• 103198-44-3 4-(2,3-Dichloro-phenyl)-2-[2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-ethoxymethyl]-6-methyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-ethyl ester 5-(2-methoxy-ethyl) ester 
• 140171-52-4 4-(2,3-Dichloro-phenyl)-2-[2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-ethoxymethyl]-6-methyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid 5-(2-dimethylamino-ethyl) ester 3-ethyl ester 
• 140171-53-5 4-(2,3-Dichloro-phenyl)-2-[2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-ethoxymethyl]-6-methyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid 5-[2-(benzyl-methyl-amino)-ethyl] ester 3-ethyl ester 
• 400024-08-0 ethyl 2-(2-chlorobenzylidene)-4-[(2-phthalimido)ethoxy]acetoacetate 
• 88150-62-3 4-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-2-[2-phthalimidoethoxymethyl]-1,4-dihydropyridine 
• 845744-00-5 ethyl 2-{[2-(1,3-dioxoisoindolin-2-yl)ethoxy]methyl}-4-(2-chlorophenyl)-5-cyano-6-methyl-1,4-dihydropyridine-3-carboxylate 
• 93849-02-6 2-({2-[(morpholinosulfonyl)amino]ethoxy}methyl)-4-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-1,4-dihydropyridine 
• 93118-29-7 2-(2-aminoethoxymethyl)-4-(2-chloro-3-trifluoromethylphenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-1,4-dihydropyridine 
• 118070-96-5 2-(2-Amino-ethoxymethyl)-4-(3-chloro-phenyl)-6-methyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-ethyl ester 5-methyl ester 
• 88150-42-9 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-1,4-dihydropyridine 
• 120289-19-2 4-(2-chlorophenyl)-5-(2-cyanoethoxycarbonyl)-3-ethoxycarbonyl-6-methyl-2-(2-phtalimidoethoxymethyl)pyridine 
• 113994-38-0 2-(aminoethoxymethyl)-5-carboxy-4-(2-chlorophenyl)-3-ethoxycarbonyl-6-methylpyridine 
• 873553-09-4 2-[2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-ethoxymethyl]-4-(3-methoxy-4-oxo-2-phenyl-4H-chromen-8-yl)-6-methyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid 5-allyl ester 3-ethyl ester 

Relevant articles and documents

Method for preparing amlodipine besylate intermediate by using micro-reaction device

The invention provides a method for producing an amlodipine besylate intermediate by using a micro-reaction device. According to the method, o-chlorobenzaldehyde is used as a raw material, the amlodipine besylate intermediate is rapidly and safely prepared by using the micro-reaction device, and the method has the advantages of high reaction conversion rate, simple post-treatment, small reaction volume, short reaction time, low energy consumption and the like, and has relatively high commercial value.

Preparation method of amlodipine key intermediate

The invention discloses a preparation method of an amlodipine key intermediate, which relates to the field of drug synthesis. The preparation method comprises the following specific steps of reactinga compound 3 (2-(2-(2-hydroxyethoxy) ethyl) isoindoline-1, 3-diketone) with DMSO (dimethyl sulfoxide) and oxalyl chloride to obtain a compound 2 (2-(2-(1, 3-dioxaisoindoline-2-yl) ethoxy) acetaldehyde), then, enabling the compound 2 and ethyl diazoacetate to be subjected to a C-H bond insertion reaction under the catalysis of Lewis (Lewis) acid, and acquiring a compound 1 ((2-(1, 3-dioxaisoindoline-2-yl) ethoxy)-3-oxabutyrate). According to the preparation method, a NaH route commonly adopted in current production is avoided, the total yield is equivalent to that of the NaH route, and the rawmaterials are cheaper and easier to obtain, so that the safety and the production efficiency are greatly improved, the total cost is reduced by about 30%, and the preparation method is suitable for industrial production.

Synthesis process of amlodipine besylate

The invention discloses a synthesis process of amlodipine besylate, relates to the technical field of medicine synthesis and solves the problems of low product purity and poor product quality controllability of products prepared by the existing synthesis process. According to the synthesis process, phthalic anhydride is used as raw materials; the parameters of the synthesis process are controlled;the technical flow process is shortened; the synthesis cost is reduced; the product yield is as high as 91 percent; the purity of the prepared amlodipine besylate is as high as 99.5 percent. The self-made amlodipine besylate are used as raw materials for further preparing the amlodipine besylate tablets; the product cost is reduced; the product quality controllability is high.