400024-08-0

Basic information

• Product Name: Butanoic acid, 2-[(2-chlorophenyl)methylene]-4-[2-(1,3-dihydro-1,3-dioxo-2H-isoindol- 2-yl)ethoxy]-3-oxo-, ethyl ester
• CAS NO: 400024-08-0
• Molecular Formula: C23H20ClNO6
• Molecular Weight: 441.868
• Mol File: 400024-08-0.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Butanoic acid, 2-[(2-chlorophenyl)methylene]-4-[2-(1,3-dihydro-1,3-dioxo-2H-isoindol- 2-yl)ethoxy]-3-oxo-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Butanoic acid, 2-[(2-chlorophenyl)methylene]-4-[2-(1,3-dihydro-1,3-dioxo-2H-isoindol- 2-yl)ethoxy]-3-oxo-, ethyl ester(400024-08-0)
• EPA Substance Registry System: Butanoic acid, 2-[(2-chlorophenyl)methylene]-4-[2-(1,3-dihydro-1,3-dioxo-2H-isoindol- 2-yl)ethoxy]-3-oxo-, ethyl ester(400024-08-0)

Safety Data

• Hazardous Substances Data: 400024-08-0(Hazardous Substances Data)

Upstream product

• 13176-46-0 4-bromoethyl acetoacetate 
• 1074-82-4 potassium phtalimide 
• 85-44-9 phthalic anhydride 
• 3891-07-4 N-(2-Hydroxyethyl)phthalimide 
• 89-98-5 2-chloro-benzaldehyde 
• 88150-75-8 ethyl 4-[2-(phthalimido)ethoxy]acetoacetate 

Downstream Products

• 88150-62-3 4-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-2-[2-phthalimidoethoxymethyl]-1,4-dihydropyridine 
• 223734-99-4 ethylmethyl-2,6-bis-[(2-phthalimidoethoxy)methyl]-4-(2-chlorophenyl)-1,4-dihydropyridine-3,5-dicarboxylate 

Relevant articles and documents

Method for preparing amlodipine besylate intermediate by using micro-reaction device

The invention provides a method for producing an amlodipine besylate intermediate by using a micro-reaction device. According to the method, o-chlorobenzaldehyde is used as a raw material, the amlodipine besylate intermediate is rapidly and safely prepared by using the micro-reaction device, and the method has the advantages of high reaction conversion rate, simple post-treatment, small reaction volume, short reaction time, low energy consumption and the like, and has relatively high commercial value.

ISOLATION OF DIHYDROPYRIDINE DERIVATIVE AND PREPARATION SALTS THEREOF

The title compound is isolated in pure form by using a crystallization process and converted to its pharmaceutically acceptable salts. The crystallization process affects stability and purity of the amlodipine salts. All known impurities and one unknown impurity, which forms during the synthesis of the amlodipine salts, were isolated, characterized, and synthesized. A new method allowing the quantitative HPLC analysis of all related impurities of amlodipine salts in a single chromatogram was developed.