88150-62-3

Basic information

• Product Name: Phthaloyl amlodipine
• Synonyms: 3-Ethyl-5-methyl-4-(2-chlorophenyl)-2-(2-phthalimidoethoxyl)methyl-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate;4-(2-Chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-2-(phthalimidoethoxy)methyl-1,4-dihydropyridine;Phthalimidoamlodipine;3-ethyl 5-methyl 4-(2-chlorophenyl)-1,4-dihydro-2-[2-(1,3-dihydro-1,3-dioxo-(2H)isoindol-2-yl)-ethoxymethyl]-6-methyl-3,5-pyridinedicarboxylate;1-Amino-6-fluoro-1,4-dihydro-7-(4-((5-methyl-2-oxo-1,3-dioxol-4-yl)methyl)piperazin-1-yl)-4-oxo-[1,3]thiazeto[3,2-A]quinoline-3-carboxylic acid;3,5-Pyridinedicarboxylicacid,4-(2-chlorophenyl)-2-[[2-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)ethoxy]Methyl]-1,4-dihydro-6-Methyl-,3-ethyl 5-Methyl ester;4-(2-Chlorophenyl)-3-Ethoxy carbonyl-5-Methoxy carbonil-6-Methyl-2-(phthaliMidoethoxy)Methyl-1,4-dihydropyridine;4-(2-Chlorophenyl)-2-[[2-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)ethoxy]Methyl]-1,4-dihydro-6-Methyl-3,5-pyridinedicarboxylic Acid 3-Ethyl 5-Methyl Ester
• CAS NO: 88150-62-3
• Molecular Formula: C₂₈H₂₇ClN₂O₇
• Molecular Weight: 538.98
• EINECS: 413-410-3
• Product Categories: API intermediates;Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 88150-62-3.mol
• Article Data: 16

Chemical Properties

• Melting Point: 140-145°C
• Boiling Point: 654.061 °C at 760 mmHg
• Flash Point: 349.364 °C
• Appearance: /
• Density: 1.321 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.589
• Storage Temp.: Refrigerator
• Solubility: DMSO (Slightly), Methanol (Slightly, Heated and Sonicated)
• PKA: 2.06±0.70(Predicted)
• CAS DataBase Reference: Phthaloyl amlodipine(CAS DataBase Reference)
• NIST Chemistry Reference: Phthaloyl amlodipine(88150-62-3)
• EPA Substance Registry System: Phthaloyl amlodipine(88150-62-3)

Safety Data

• Statements: 53
• Safety Statements: 61
• Hazardous Substances Data: 88150-62-3(Hazardous Substances Data)

Usage

Chemical Properties

Pale Yellow Solid

Uses

Different sources of media describe the Uses of 88150-62-3 differently. You can refer to the following data:
1. Amilodopine intermediate
2. Amlodipine intermediate. Amlodipine Related Compound A
3. Amlodipine intermediate.

InChI:InChI=1/C28H27ClN2O7/c1-4-38-28(35)24-21(15-37-14-13-31-25(32)17-9-5-6-10-18(17)26(31)33)30-16(2)22(27(34)36-3)23(24)19-11-7-8-12-20(19)29/h5-12,23,30H,4,13-15H2,1-3H3

Upstream product

• 89-98-5 2-chloro-benzaldehyde 
• 14205-39-1 methyl (E)-3-aminocrotonate 
• 88150-75-8 ethyl 4-[2-(phthalimido)ethoxy]acetoacetate 
• 400024-08-0 ethyl 2-(2-chlorobenzylidene)-4-[(2-phthalimido)ethoxy]acetoacetate 
• 14205-39-1 methyl 3-aminocrotonate 
• 13176-46-0 4-bromoethyl acetoacetate 
• 1074-82-4 potassium phtalimide 
• 85-44-9 phthalic anhydride 
• 265136-65-0 ethyl (E)-3-amino-4-[2-(phthalimido)ethoxy]crotonate 
• 67593-46-8 methyl (Z)-2-acetyl-3-(2-chlorophenyl)acrylate 
• 21731-17-9 methyl 3-aminocrotonate 
• 638-07-3 ethyl (2-chloroaceto)acetate 
• 3891-07-4 N-(2-Hydroxyethyl)phthalimide 

Downstream Products

• 1064653-84-4 acetone solvate of 3-ethyl, 5-methyl 4-(2-chlorophenyl)-1,4-dihydro-6-methyl-2-[(2-phthalimidoethoxy)methyl]-3,5-pyridinedicarboxylate 
• 111470-99-6 amlodipine besylate 
• 88150-47-4 (RS)-amlodipine maleate 
• 721958-72-1 3-ethyl-5-methyl-(4-RS)-4-(2-chlorophenyl)-6-[[2-((2-methylcarbamoyl)benzoyl)aminoethoxy]methyl]-1,4-dihydropyridine-3,5-dicarboxylate 
• 93849-02-6 2-({2-[(morpholinosulfonyl)amino]ethoxy}methyl)-4-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-1,4-dihydropyridine 
• 113994-41-5 2-(2-Amino-ethoxymethyl)-4-(2-chloro-phenyl)-6-methyl-pyridine-3,5-dicarboxylic acid 3-ethyl ester 5-methyl ester 
• 88150-42-9 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-1,4-dihydropyridine 

Relevant articles and documents

Method for preparing amlodipine besylate intermediate by using micro-reaction device

The invention provides a method for producing an amlodipine besylate intermediate by using a micro-reaction device. According to the method, o-chlorobenzaldehyde is used as a raw material, the amlodipine besylate intermediate is rapidly and safely prepared by using the micro-reaction device, and the method has the advantages of high reaction conversion rate, simple post-treatment, small reaction volume, short reaction time, low energy consumption and the like, and has relatively high commercial value.

Synthesis process of amlodipine besylate

The invention discloses a synthesis process of amlodipine besylate, relates to the technical field of medicine synthesis and solves the problems of low product purity and poor product quality controllability of products prepared by the existing synthesis process. According to the synthesis process, phthalic anhydride is used as raw materials; the parameters of the synthesis process are controlled;the technical flow process is shortened; the synthesis cost is reduced; the product yield is as high as 91 percent; the purity of the prepared amlodipine besylate is as high as 99.5 percent. The self-made amlodipine besylate are used as raw materials for further preparing the amlodipine besylate tablets; the product cost is reduced; the product quality controllability is high.

Using the new crystal form [...] and production of high-purity [...]

PROBLEM TO BE SOLVED: To provide a process for producing high-purity phthaloyl amlodipine for synthesis of an amlodipine besilate having excellent purity as a medicine.SOLUTION: Provided are TW-A type and TW-B type crystal forms of highly pure phthaloyl amlodipine. In powder X-ray diffraction, the TW-A type phthaloyl amlodipine has diffraction peaks at 2θ(°)=8.7±0.2, 11.0±0.2, 13.4±0.2, 15.7±0.2, and 24.6±0.2. In powder X-ray diffraction, the TW-B type phthaloyl amlodipine has diffraction peaks at 2θ(°)=6.6±0.2, 9.9±0.2, 11.1±0.2, 17.3±0.2, and 24.4±0.2.