84736-47-0

Basic information

• Product Name: Morpholine, 4-[4-(1,1-dimethylethyl)phenyl]-
• CAS NO: 84736-47-0
• Molecular Formula: C14H21NO
• Molecular Weight: 219.327
• Mol File: 84736-47-0.mol
• Article Data: 44

Chemical Properties

• CAS DataBase Reference: Morpholine, 4-[4-(1,1-dimethylethyl)phenyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Morpholine, 4-[4-(1,1-dimethylethyl)phenyl]-(84736-47-0)
• EPA Substance Registry System: Morpholine, 4-[4-(1,1-dimethylethyl)phenyl]-(84736-47-0)

Safety Data

• Hazardous Substances Data: 84736-47-0(Hazardous Substances Data)

Upstream product

• 110-91-8 morpholine 
• 35779-04-5 1-tert-butyl-4-iodobenzene 
• 3972-65-4 1-bromo-4-tert-butylbenzene 
• 154318-75-9 4-tert-butylphenyl triflate 
• 16963-28-3 4-t-butyl-1-(morpholin-4-yl)cyclohex-1-ene 
• 247018-51-5 4-t-butylphenyl 1,1,2,2,3,3,4,4,4-nonafluorobutane-1-sulfonate 
• 98-53-3 4-tercbutyl-cyclohexanone 
• 7252-86-0 4-tert-butylthioanisole 
• 5765-65-1 4-(benzoyloxy)morpholine 
• 58164-02-6 1-(tert-butyl)-3-iodobenzene 
• 109-02-4 4-methyl-morpholine 
• 1315568-69-4 4-(tert-butyl)-2-(trimethylsilyl)phenyl trifluoromethanesulfonate 
• 4783-74-8 2-(4-(tert-butyl)phenoxy)pyridine 
• 98-54-4 para-tert-butylphenol 

Downstream Products

• 905966-37-2 2-(4-(tert-butyl)phenyl)-5,5-dimethyl-1,3,2-dioxaborinane 

Relevant articles and documents

Use of polymer-supported dialkylphosphinobiphenyl ligands for palladium-catalyzed amination and Suzuki reactions

The preparations of polymer-supported dialkylphosphinobiphenyl ligands (3) are reported. A palladium catalyst based on ligand 3a is active for amination and Suzuki reactions using unactivated aryl iodides, bromides, or chlorides. Filtration of the catalyst from the reaction mixtures allows for simplified product isolation via an aqueous workup. The resin-bound catalyst can be recycled without additional palladium in both the amination and Suzuki reactions.

(DiMeIHeptCl)Pd: A Low-Load Catalyst for Solvent-Free (Melt) Amination

(DiMeIHeptCl)Pd, a hyper-branched N-aryl Pd NHC catalyst, has been shown to be efficient at performing amine arylation reactions in solvent-free ("melt") conditions. The highly lipophilic environment of the alkyl chains flanking the Pd center serves as lubricant to allow the complex to navigate through the paste-like environment of these mixtures. The protocol can be used on a multi-gram scale to make a variety of aniline derivatives, including substrates containing alcohol moieties.

Nickel-Catalyzed Amination of Aryl Thioethers: A Combined Synthetic and Mechanistic Study

Herein, we report a nickel-1,2-bis(dicyclohexylphosphino)ethane (dcype) complex for the catalytic Buchwald-Hartwig amination of aryl thioethers. The protocol shows broad applicability with a variety of different functional groups tolerated under the catalytic conditions. Extensive organometallic and kinetic studies support a nickel(0)-nickel(II) pathway for this transformation and revealed the oxidative addition complex as the resting state of the catalytic cycle. All the isolated intermediates have proven to be catalytically and kinetically competent catalysts for this transformation. The fleeting transmetalation intermediate has been successfully synthesized through an alternative synthetic organometallic pathway at lower temperature, allowing for in situ NMR study of the C-N bond reductive elimination step. This study addresses key factors governing the mechanism of the nickel-catalyzed Buchwald-Hartwig amination process, thus improving the understanding of this important class of reactions.