848260-89-9

Basic information

• Product Name: Phenol, 3-[[2-benzoxazolyl[3-(4-methoxyphenoxy)propyl]amino]methyl]-
• Synonyms: N-(benzoxazole-2-yl)-N-(3-(4-methoxyphenoxy)propyl)-3-hydroxybenzylamine;N-(benzoxazol-2-yl)-N-[3-(4-methoxyphenoxy)propyl]-3-hydroxy-benzylamine;N-(benzoxazol-2-yl)-N-3-(4-methoxyphenoxy)propyl-3-hydroxybenzylamine
• CAS NO: 848260-89-9
• Molecular Formula: C24H24N2O4
• Molecular Weight: 404.466
• Mol File: 848260-89-9.mol
• Article Data: 3

Chemical Properties

• Melting Point: 103 - 104 °C (tert-butyl methyl ether)
• CAS DataBase Reference: Phenol, 3-[[2-benzoxazolyl[3-(4-methoxyphenoxy)propyl]amino]methyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Phenol, 3-[[2-benzoxazolyl[3-(4-methoxyphenoxy)propyl]amino]methyl]-(848260-89-9)
• EPA Substance Registry System: Phenol, 3-[[2-benzoxazolyl[3-(4-methoxyphenoxy)propyl]amino]methyl]-(848260-89-9)

Safety Data

• Hazardous Substances Data: 848260-89-9(Hazardous Substances Data)

Upstream product

• 615-18-9 2-chloro-1,3-benzoxazole 
• 907192-58-9 3-({[3-(4-methoxyphenoxy)propyl]amino}methyl)phenol 
• 848260-88-8 N-(benzoxazol-2-yl)-N-3-(4-methoxyphenoxy)propyl-3-tert-butyldimethylsilyloxybenzylamine 

Downstream Products

• 848258-31-1 (2R)-2-[3-[[1,3-benzoxazol-2-yl-[3-(4-methoxyphenoxy)propyl]amino]methyl]phenoxy]butanoic acid 
• 907192-61-4 n-butyl (R)-2-[3-[[benzoxazol-2-yl-[3-(4-methoxyphenoxy)propyl]amino]methyl]phenoxy]butanoate 
• 848260-90-2 ethyl (R)-2-[3-[[N-(benzoxazol-2-yl)-N-3-(4-methoxyphenoxy)propyl]aminomethyl]phenoxy]propionate 
• 916515-10-1 (R)-3-[3-({benzoxazol-2-yl[3-(4-methoxyphenoxy)propyl]amino}methyl)phenoxy]dihydrofuran-2(3H)-one 

Relevant articles and documents

Enantioselective synthesis of the PPARα agonist (R)-K-13675 via (S)-2-hydroxybutyrolactone

Enantioselective synthesis of enantiomerically pure PPARα agonist (R)-K-13675 can be achieved starting from (S)-2-hydroxybutyrolactone. An important intermediate, 2-(aryloxy)butyrolactone, was prepared by reaction of the phenol with (S)-2-hydroxybutyrolactone in excellent yield without loss of enantiomeric purity using the Mitsunobu reaction, followed by conversion into the 2-(aryloxy)butanoic acid via the 2-(aryloxy)-4-iodobutanoate by cleavage of the lactone on exposure to iodotrimethylsilane, followed by hydrogenolysis and hydrolysis. Georg Thieme Verlag Stuttgart.

PPAR-activating compound and pharmaceutical composition comprising the compound

A compound represented by the following formula (1): Or a salt thereof; and therapeutic durgs containing the compound. The compound selectively activates PPARα.