84839-56-5 Usage
Description
(1-tert-butoxycarbonyl-1,2,5,6-tetrahydropyridin-4-yl)acetic acid ethyl ester is a complex organic compound featuring a tetrahydropyridine ring with an acetic acid and ethyl ester functional group. The presence of the tert-butoxycarbonyl (Boc) group serves as a protective agent for the amine functional group within the tetrahydropyridine ring, enabling selective reactions at alternative sites on the molecule. (1-tert-butoxycarbonyl-1,2,5,6-tetrahydropyridin-4-yl)acetic acid ethyl ester plays a pivotal role in drug discovery and development, as well as in the synthesis of intricate organic molecules for a variety of applications in the fields of chemistry and biology.
Uses
Used in Organic Synthesis:
(1-tert-butoxycarbonyl-1,2,5,6-tetrahydropyridin-4-yl)acetic acid ethyl ester is utilized as a key building block in organic synthesis, facilitating the creation of diverse chemical compounds. Its unique structure allows for a range of reactions, making it a valuable component in the synthesis of complex organic molecules.
Used in Pharmaceutical Research:
In the pharmaceutical industry, (1-tert-butoxycarbonyl-1,2,5,6-tetrahydropyridin-4-yl)acetic acid ethyl ester is employed as an intermediate in the preparation of various medicinal compounds. Its ability to undergo selective reactions, due to the Boc protecting group, makes it an advantageous starting material for the development of new drugs.
Used in Drug Discovery and Development:
(1-tert-butoxycarbonyl-1,2,5,6-tetrahydropyridin-4-yl)acetic acid ethyl ester is also crucial in drug discovery and development, where its structural attributes can be leveraged to design and synthesize potential therapeutic agents. The Boc group's protective role ensures that the tetrahydropyridine ring can be selectively modified, which is essential for optimizing the pharmacological properties of the resulting drug candidates.
Used in Chemistry and Biology:
(1-tert-butoxycarbonyl-1,2,5,6-tetrahydropyridin-4-yl)acetic acid ethyl ester finds applications across various sectors of chemistry and biology, where its unique structure and reactivity contribute to the advancement of scientific research and the development of novel applications.
Check Digit Verification of cas no
The CAS Registry Mumber 84839-56-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,4,8,3 and 9 respectively; the second part has 2 digits, 5 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 84839-56:
(7*8)+(6*4)+(5*8)+(4*3)+(3*9)+(2*5)+(1*6)=175
175 % 10 = 5
So 84839-56-5 is a valid CAS Registry Number.
84839-56-5Relevant articles and documents
Synthesis of piperidine derivatives fused to a tetrahydrofuran ring
Moskalenko,Boev
, p. 54 - 58 (2014)
Intramolecular nucleophilic opening of the oxirane ring in tert-butyl 6-(2-hydroxyethyl)-7-oxa-3-azabicyclo[4.1.0]heptane-3-carboxylate by the action of excess potassium hydroxide in 75% aqueous dimethyl sulfoxide at 110-120 C gave tert-butyl (3aR,7aS)-3a-hydroxyhexahydrofuro[2,3-c]pyridine-6(2H)- carboxylate whose treatment with POCl3 resulted in elimination of water molecule and tert-butoxycarbonyl group with formation of 2,3,4,5,6,7-hexahydrofuro[2,3-c]pyridine hydrochloride. The latter reacted with electrophiles (acetic anhydride, methanesulfonyl chloride, and benzaldehyde in combination with sodium triacetoxyhydridoborate) in the presence of triethylamine, yielding the corresponding N-substituted 2,3,4,5,6,7- hexahydrofuro[ 2,3-c]pyridine derivatives.
Synthesis of the selective muscarinic agonist (3R)-3-(6-chloropyrazin-2-yl)-1-azabicyclooctane
Ashwood, Michael S.,Gibson, Andrew W.,Houghton, Peter G.,Humphrey, Guy R.,Roberts, D. Craig,Wright, Stanley H. B.
, p. 641 - 644 (2007/10/02)
The synthesis of the functionally selective muscarinic agonist (3R)-3-(6-chloropyrazin-2-yl)-1-azabicyclooctane is described commencing from readily available 4-piperidone.The key feature of this novel process is the preparation and resolution of a piperidin-4-ylacetic acid, with the advantage that high yields of the pure (S)-enantiomer may be obtained by epimerization of the unwanted enantiomer for further resolution.The reaction sequence is completed by reduction to a chiral 4-hydroxyethylpiperidine and intramolecular N-alkylation to the bicycle 1.
