848653-50-9Relevant articles and documents
Synthesis and biological activity of the tea catechin metabolites, M4 and M6 and their methoxy-derivatives
Lambert, Joshua D.,Rice, Joseph E.,Hong, Jungil,Hou, Zhe,Yang, Chung S.
, p. 873 - 876 (2007/10/03)
Syntheses are reported for metabolites M4 (1) and M6 (2) of the green tea polyphenols epicatechin (EC) and epigallocatechin (EGC) and their gallate derivatives. Several methoxy-derivatives of 1 and 2 were also prepared. Compounds 1 and 2 were evaluated for growth inhibitory activity against a panel of immortalized and malignant human cell lines with 1 being the more active compound. The possible antiinflammatory activity of 1 and its trimethoxy derivative was also evaluated. Neither compound inhibited the release of arachidonic acid, although 1 inhibited NO production by 50% at 20 μM.