84889-09-8Relevant articles and documents
Two approaches for the engineering of homogeneous small-molecule hydrogels
Ding, Baiyong,Li, Ying,Qin, Meng,Ding, Yin,Cao, Yi,Wang, Wei
, p. 4672 - 4680 (2013)
Small-molecule hydrogelators have been widely used to engineer supramolecular hydrogels for biomedical applications. Typically, a change of the solubility of small molecules in solvent is used to trigger the gelation process. This requires a switch of pH or solvent by mixing two different types of solutions. However, due to the intrinsic ragged free energy landscape that underlies the self-assembly process and the high viscosity of the solution that limits the diffusion, the hydrogels made by these methods are often limited by their inhomogeneity and irreproducible physical properties. It is therefore desirable to circumvent these drawbacks and produce homogeneous hydrogels. Conversely, only a few studies have been done towards this direction. In this article, we present two novel approaches to engineer homogeneous hydrogels. One is based on the nano-dispersed colloids to hydrogel transition and the other is based on the decomposition of potassium persulfate to mildly change the pH. These two methods allow kinetically controlling the self-assembly process and the resulting hydrogels are indeed more homogeneous and reproducible. Moreover, the structural and morphological characterizations suggest that the structures of the hydrogels prepared by different approaches are distinct from each other, leading to diverse macroscopic mechanical properties. These results suggest that besides the thermodynamics, the self-assembly kinetics also plays an important role in determining the properties of the final assembled hydrogels. We propose that it is possible to rationally tune the physical properties of the hydrogels by simply control the self-assembly kinetics without changing the structure of the small-molecule hydrogelators.
Benzoisothiazolone (BIT): A Fast, Efficient, and Recyclable Redox Reagent for Solid Phase Peptide Synthesis
Bukya, Hemalatha,Gangireddy, Pavankumar,Mainkar, Prathama S.,Nayani, Kiranmai
supporting information, p. 5358 - 5362 (2020/08/27)
Solid-phase peptide synthesis (SPPS), a preferred synthetic procedure, generates by-products and effluents in multiple equivalents for one equivalent of desired product. Presented herein is the use of a fast and efficient coupling protocol for SPPS using a benzoisothiazolone (BIT), which can be fully recycled. The BIT, as redox activator, works under very mild conditions and generates minimal amount of waste. As a case study, the BIT coupling protocol is applied to the synthesis of side chain of the recently discovered antibiotic, teixobactin.
Regulating Higher-Order Organization through the Synergy of Two Self-Sorted Assemblies
Ji, Wei,Zhang, Shijin,Yukawa, Sachie,Onomura, Shogo,Sasaki, Toshio,Miyazawa, Kun'ichi,Zhang, Ye
supporting information, p. 3636 - 3640 (2018/03/06)
The extracellular matrix (ECM) is the natural fibrous scaffold that regulates cell behavior in a hierarchical manner. By mimicking the dynamic and reciprocal interactions between ECM and cells, higher-order molecular self-assembly (SA), mediated through the dynamic growth of scaffold-like nanostructures assembled by different molecular components, was developed. Designed and synthesized were two self-sorted coumarin-based gelators, a peptide molecule and a benzoate molecule, which self-assemble into nanofibers and nanobelts, respectively, with different dynamic profiles. Upon the dynamic growth of the fibrous scaffold assembled from peptide gelators, nanobelts assembled from benzoate gelators transform into a layer-by-layer nanosheet, reaching ninefold increase in height. By using light and an enzyme, the spatial–temporal growth of the scaffold can be modified, leading to in situ height regulation of the higher-order architecture.
