85102-26-7

Basic information

• Product Name: 2,3-diphenylimidazo[1,2-a]pyridine
• Synonyms: 2,3-diphenylimidazo[1,2-a]pyridine
• CAS NO: 85102-26-7
• Molecular Formula: C₁₉H₁₄N₂
• Molecular Weight: 270.32786
• Mol File: 85102-26-7.mol
• Article Data: 44

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2,3-diphenylimidazo[1,2-a]pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3-diphenylimidazo[1,2-a]pyridine(85102-26-7)
• EPA Substance Registry System: 2,3-diphenylimidazo[1,2-a]pyridine(85102-26-7)

Safety Data

• Hazardous Substances Data: 85102-26-7(Hazardous Substances Data)

Usage

General Description

2,3-diphenylimidazo[1,2-a]pyridine is a chemical compound with a unique structure that consists of an imidazole and a pyridine ring fused together. It is primarily used in medicinal chemistry for the development of new drugs, particularly for its potential anti-cancer and anti-tumor properties. Research has shown that this compound can inhibit the growth of cancer cells and induce cell death in cancerous tissues. Additionally, it has also been studied for its potential anti-inflammatory and antimicrobial properties. Its unique structure and diverse biological activities make it a promising candidate for further development in the field of drug discovery and pharmaceutical research.

Upstream product

• 64413-90-7 3-iodo-2-phenylimidazo[1,2-α]pyridine 
• 98-80-6 phenylboronic acid 
• 4105-21-9 2-phenylimidazo[1,2-a]pyridine 
• 71-43-2 benzene 
• 110-86-1 pyridine 
• 19690-01-8 1,2-diphenylethanone O-acetyl oxime 
• 123533-41-5 2-phenylimidazo[1,2-a]pyridine-3-carboxylic acid 
• 108-90-7 chlorobenzene 
• 504-29-0 2-aminopyridine 
• 447-31-4 Desyl chloride 
• 103-29-7 1,1'-(1,2-ethanediyl)bisbenzene 
• 24242-77-1 α-iodo-α-phenylacetophenone 
• 4044-95-5 2-Phenyl-3-bromoimidazo<1,2-a>pyridine 
• 591-50-4 iodobenzene 

Relevant articles and documents

A multi pathway coupled domino strategy: I2/ TBHP-promoted synthesis of imidazopyridines and thiazoles via sp3, sp2 and sp C-H functionalization

I2/TBHP-promoted, one-pot, multi pathway synthesis of imidazopyridines and thiazoles has been achieved through readily available ethylarenes, ethylenearenes and ethynearenes. I2/TBHP as an initiator and oxidant is used to realize the C-H functionalization of this domino reaction. Simple and available starting materials, wide range of functional group tolerance, high potential for drug activity of the products and application in production are the advantageous features of this method.

Diversity-oriented synthesis toward aryl- And phosphoryl-functionalized imidazo[1,2-a]pyridines

We report herein an efficient synthesis of diversely polysubstituted imidazo[1,2-a]pyridines, a family of aza-heterocycles endowed with numerous biological properties, through a sequence involving two consecutive palladium-catalyzed cross-coupling reactions. First, we demonstrated that a Hirao coupling occurred straightforwardly in high yields at positions 3, 5, and 6 of imidazopyridine derivatives, giving access to a wide variety of substituted phosphonates, phosphinates, and phosphine oxides. In a second step, direct CH-arylation of phosphorylimidazopyridines with aryl halides was found to be effective and fully selective, leading to 3-aryl-substituted imidazopyridines in moderate to high yields depending on steric hindrance.

An insight into the novel covalent functionalization of multi-wall carbon nanotubes with pseudopeptide backbones for palladium nanoparticles immobilization: A versatile catalyst towards diverse cross-coupling reactions in bio-based solvents

Materials functionalization with multicomponent reactions (MCRs) has grabbed a lot of attention nowadays due to the integration of outstanding features of MCRs with materials domains. Herein, we put the spotlight on the isocyanides and Meldrum's acid-based MCRs route for the one-pot covalent functionalization of multi-wall carbon nanotubes (MWCNTs) which led to pseudopeptide-decorated MWCNTs with the ability to immobilized palladium nanoparticles and serve as a neoteric catalytic system. Characterization of the synthesized nanocatalyst was carried out by FT-IR, 1H NMR, XRD, SEM, TEM, EDX and TGA. The catalytic activities of the nanocatalyst for diverse carbon-carbon cross-coupling reactions were examined in bio-based solvents. The results showed the catalytic performance of the nanocatalyst for the formation of Csp2-Csp2, Csp-Csp2 and Csp-Csp bonds through homocoupling and intermolecular Ullmann, C[sbnd]H arylation, Mizoroki-Heck, Sonogashira and Glaser coupling reactions with considerable improvements in the yield, reaction times, bio-based media and chemoselectivity of the procedures. Additionally, this method demonstrated a high potential for recycling of heterogeneous catalysts by maintaining their initial performances without any evidence of the Pd leaching.