851025-45-1

Basic information

• Product Name: 1H-Pyrrol-1-yloxy, 3-[[[2-[4-[(2-butyl-3-benzofuranyl)carbonyl]-2,6-diiodophenoxy]ethyl]ethyl amino]methyl]-2,5-dihydro-2,2,5,5-tetramethyl-
• CAS NO: 851025-45-1
• Molecular Formula: C32H39I2N2O4
• Molecular Weight: 769.482
• Mol File: 851025-45-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1H-Pyrrol-1-yloxy, 3-[[[2-[4-[(2-butyl-3-benzofuranyl)carbonyl]-2,6-diiodophenoxy]ethyl]ethyl amino]methyl]-2,5-dihydro-2,2,5,5-tetramethyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Pyrrol-1-yloxy, 3-[[[2-[4-[(2-butyl-3-benzofuranyl)carbonyl]-2,6-diiodophenoxy]ethyl]ethyl amino]methyl]-2,5-dihydro-2,2,5,5-tetramethyl-(851025-45-1)
• EPA Substance Registry System: 1H-Pyrrol-1-yloxy, 3-[[[2-[4-[(2-butyl-3-benzofuranyl)carbonyl]-2,6-diiodophenoxy]ethyl]ethyl amino]methyl]-2,5-dihydro-2,2,5,5-tetramethyl-(851025-45-1)

Safety Data

• Hazardous Substances Data: 851025-45-1(Hazardous Substances Data)

Upstream product

• 76893-32-8 3-(bromomethyl)-2,5-dihydro-2,2,5,5-tetramethyl-1H-pyrrol-1-oxyl 
• 851025-44-0 3-{[ethyl-(2-hydroxyethyl)-amino]-methyl}-2,2,5,5-tetramethyl-2,5-dihydro-1H-pyrrol-1-yloxyl 
• 851025-42-8 C₁₄H₂₇N₂O₄S 
• 1951-26-4 2-n-butyl-3-(3',5'-diiodo-4'-hydroxybenzoyl)benzofuran 

Relevant articles and documents

Synthesis and evaluation of the permeability transition inhibitory characteristics of paramagnetic and diamagnetic amiodarone derivatives

Several amiodarone analogues were synthesized varying the 2-substituent on the benzofuran ring and diethylaminoethyl side chain of phenolether by introducing 2,2,5,5-tetramethyl-2,5-dihydro-1H-pyrrole and 1,2,5,6- tetrahydropyridine nitroxides or their amino or hydroxylamino precursors. The new compounds were screened on isolated mitochondria and perfused heart and their toxicity was evaluated on WRL-68 liver cells and H9C2 cardiomyocytes. Most of the newly synthesized derivatives exerted uncoupling effect on the mitochondrial oxidative phosphorilation at higher concentrations, compared to amiodarone and one of the modified amiodarone analogues showed an effect similar to that of amiodarone on the mitochondrial permeability transition and on restoring of mitochondrial high-energy phosphate metabolites in perfused hearts. This amiodarone analogue can be new leading compound among the experimental amiodarone analogues with the same or enhanced efficiency of amiodarone, but with less side effects.