852395-25-6Relevant articles and documents
METHOD OF PRODUCING BICYCLO[3.1.0] HEXANE DERIVATIVE USING ENZYME
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, (2011/04/18)
Production of a bicyclo[3.1.0]hexane derivative, useful as a metabotropic glutamate receptor modulator, becomes possible by a production method that includes converting a compound represented by Formula (II) into a compound represented by Formula (III) by reaction with an acyl group donor in the presence of a microorganism-derived enzyme, without using an expensive optically active trans hydroxy ester as a starting material and without employing a fluorination reaction requiring an ultralow temperature reaction. Furthermore, since asymmetric synthesis can be carried out in a stage closer to the final product, the production method is useful as a production method that can mass produce a bicyclo[3.1.0]hexane derivative.
PROCESSES FOR PREPARING BICYCLO [3.1.0] HEXANE DERIVATIVES, AND INTERMEDIATES THERETO
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Page/Page column 30-31, (2010/02/11)
The present invention is concerned with novel processes for the preparation of certain bicyclo [3.1.0] hexane derivatives which are useful as mGluR agonists, and novel intermediates prepared during such processes.