85277-87-8

Basic information

• Product Name: (E)-3-fluoro-2-phenyl-2-propen-1-ol
• Synonyms: (E)-3-fluoro-2-phenyl-2-propen-1-ol
• CAS NO: 85277-87-8
• Molecular Weight: 152.168
• Mol File: 85277-87-8.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: (E)-3-fluoro-2-phenyl-2-propen-1-ol(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-3-fluoro-2-phenyl-2-propen-1-ol(85277-87-8)
• EPA Substance Registry System: (E)-3-fluoro-2-phenyl-2-propen-1-ol(85277-87-8)

Safety Data

• Hazardous Substances Data: 85277-87-8(Hazardous Substances Data)

Upstream product

• 17097-90-4 2-phenylmalonic acid monoethyl ester 
• 101-97-3 Ethyl 2-phenylethanoate 
• 85277-71-0 1-tert-butyl 3-ethyl 2-(difluoromethyl)-2-phenylmalonate 
• 85278-30-4 ethyl 2-(tert-butoxycarbonyl)-2-(bromodifluoromethyl)phenylacetate 
• 85277-62-9 ethyl 2-(tert-butoxycarbonyl)phenylacetate 
• 16537-09-0 t-butyl phenylacetate 
• 85278-32-6 ethyl 2-phenyl-3,3-difluoroacrylate 
• 85277-78-7 ethyl (E)-3-fluoro-2-phenylacrylate 

Downstream Products

• 843651-82-1 N-[(E)-(2-phenyl-3-fluoroallyl)]-N-tert-butoxycarbonylaminophthalimide 
• 879221-61-1 2-((Z)-2-Chloro-3-phenyl-allyl)-isoindole-1,3-dione 
• 93605-81-3 1,2-dibromo-1-fluoro-2-phenyl-3-phthalimidopropane 
• 85278-69-9 (E)-2-phenyl-3-fluoroallyl alcohol 
• 93605-75-5 2-phenyl-3-fluoroallylamine 
• 85278-44-0 1-fluoro-2-phenyl-3-phthalimidopropene 
• 85278-05-3 (E)-3-fluoro-2-phenylallylamine hydrochloride 
• 85278-84-8 (Z)-3-fluoro-2-phenyl-2-propenamine hydrochloride 
• 843651-83-2 1-[(E)-2-phenyl-3-fluoroallyl]-1-tert-butyloxycarbonylhydrazine 
• 85277-96-9 (E)-1-fluoro-2-phenyl-3-phthalimidopropene 

Relevant articles and documents

Novel arylalkenylpropargylamines as neuroprotective, potent, and selective monoamine oxidase B inhibitors for the treatment of Parkinson's disease

To develop novel neuroprotective agents, a library of novel arylalkenylpropargylamines was synthesized and tested for inhibitory activities against monoamine oxidases. From this, a number of highly potent and selective monoamine oxidase B inhibitors were identified. Selected compounds were also tested for neuroprotection in in vitro studies with PC-12 cells treated with 6-OHDA and rotenone, respectively. It was observed that some of the compounds tested yielded a marked increase in survival in PC-12 cells treated with the neurotoxins. This indicates that these propargylamines are able to confer protection against the effects of the toxins and may also be considered as novel disease-modifying anti-Parkinsonian agents, which are much needed for the therapy of Parkinson's disease.

Inactivation of bovine plasma amine oxidase by haloallylamines

Various 2- and 3-haloallylamines were synthesized and evaluated as inhibitors of the quinone-dependent bovine plasma amine oxidase (BPAO). 3-Haloallylamines, which were previously found to be good inhibitors of the flavin-dependent mitochondrial monoamine

Allyl amine MAO inhibitors

Compounds of the formula STR1 wherein: R is phenyl, phenyl monosubstituted, disubstituted, or trisubstituted by (C1 -C8) alkyl, (C1 -C8)alkoxy, hydroxy, chlorine, bromine, iodine, fluorine, trifluoromethyl, nitr