85381-22-2

Basic information

• Product Name: BZ-DMT-DEOXYADENOSINE 2-CLPH DIESTER TRIETHYLAMMONIUM SALT
• Synonyms: BZ-DMT-DEOXYADENOSINE 2-CLPH DIESTER TRIETHYLAMMONIUM SALT;bz-dmt-deoxyadenosine 2-clph diester*triethylammo;3'-Adenylic acid, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-, mono(2-chlorophenyl) ester, compd. with N,N-diethylethanamine (1:1);BZ-DMT-DEOXYADENOSINE 2-CLPH DIESTERTRIE THYLAMMONI;n6-benzoyl-5'-o-(4,4'-dimethoxytrityl)-2'-deoxyadenosine 3'-(2-chlorophenyl) phosphate triethylammonium salt;N(sup 6)benzoyl-5'-O-(4,4'-dimethoxytrityl)-2-deoxyaden...;3'-Adenylic acid, N-benzoyl-5'-o-(bis(4-methoxyphenyl)phenylmethyl)-2'-deoxy-, mono(2-chlorophenyl) ester, compd. with N,N-diethylethanamine (1:1);Einecs 286-750-1
• CAS NO: 85381-22-2
• Molecular Formula: C₆H₁₅N*C₄₄H₃₉ClN₅O₉P
• Molecular Weight: 848.24
• EINECS: 286-750-1
• Product Categories: Biochemicals and Reagents;Nucleosides, Nucleotides, Oligonucleotides;Nucleotide Analogs
• Mol File: 85381-22-2.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• Storage Temp.: −20°C
• CAS DataBase Reference: BZ-DMT-DEOXYADENOSINE 2-CLPH DIESTER TRIETHYLAMMONIUM SALT(CAS DataBase Reference)
• NIST Chemistry Reference: BZ-DMT-DEOXYADENOSINE 2-CLPH DIESTER TRIETHYLAMMONIUM SALT(85381-22-2)
• EPA Substance Registry System: BZ-DMT-DEOXYADENOSINE 2-CLPH DIESTER TRIETHYLAMMONIUM SALT(85381-22-2)

Safety Data

• Hazard Codes: Xn
• Statements: 20/22-36/37/38
• Safety Statements: 26
• WGK Germany: 3
• Hazardous Substances Data: 85381-22-2(Hazardous Substances Data)

Upstream product

• 15715-58-9 triethylamine carbonate 
• 64325-78-6 N₆-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyadenosine 
• 15074-54-1 2-chlorophenyl dichlorophosphate 

Downstream Products

• 127400-47-9 Phosphoric acid (2R,3S,5R)-5-(6-benzoylamino-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-yl ester 2-chloro-phenyl ester 2,5-dimethoxy-2,5-dihydro-furan-2-ylmethyl ester 
• 91592-67-5 C₈₈H₇₉Cl₂N₁₃O₂₁P₂ 
• 84758-11-2 Benzoic acid (2R,3S,5R)-5-(6-benzoylamino-purin-9-yl)-2-[{(2R,3S,5R)-5-(6-benzoylamino-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-yloxy}-(2-chloro-phenoxy)-phosphoryloxymethyl]-tetrahydro-furan-3-yl ester 
• 75269-18-0 N-benzoyl-5'-O-(bis(4-methoxyphenyl)phenylmethyl)-P-(2-chlorophenyl)-2'-deoxyadenylyl-(3'->5')-N-benzoyl-2'-deoxy-3'-cytidylic acid, 2-chlorophenyl 2-cyanoethyl ester 
• 99388-90-6 C₆₅H₆₀ClN₁₀O₁₄P 
• 75269-16-8 <(MeO)2Tr>bzA_dΦbzA_dΦ(CNEt) 
• 99388-92-8 C₈₇H₈₄Cl₃N₁₆O₂₃P₃ 

Relevant articles and documents

Improved synthesis of trinucleotide phosphoramidites and generation of randomized oligonucleotide libraries

A new method to produce a set of 20 high quality trinucleotide phosphoramidites on a 5-10 g scale each was developed. The procedure starts with condensation reactions of P-components with N-acyl nucleosides, bearing the 3′-hydroxyl function protected with 2-azidomethylbenzoyl, to give fully protected dinucleoside phosphates 13. Upon cleavage of dimethoxytrityl group from 13, dinucleoside phosphates 16 are initially transformed into trinucleoside diphosphates 19 and then the 2-azidomethylbenzoyl is selectively removed under neutral conditions to generate trinucleoside diphosphates 5 in excellent yield. Subsequent 3′-phosphitylation affords target trinucleotide phosphoramidites 7. When mutagenic oligonucleotides are synthesized employing mixtures of building blocks 7 as well as following the new synthetic protocol, representative oligonucleotide libraries are generated in good yields. Copyright Taylor & Francis Group, LLC.