85618-16-2 Usage
Description
(2-Aminoethyl)phosphinic acid, also known as 2-AEP, is an organic compound with the chemical formula HOCH2CH2NH(PHO)OH. It is a derivative of amino acids and phosphonic acid, featuring an aminoethyl group attached to a phosphinic acid moiety. This unique structure endows it with potential applications in various fields, particularly in the development of bioactive molecules and pharmaceuticals.
Uses
Used in Pharmaceutical Industry:
(2-Aminoethyl)phosphinic acid is used as a key intermediate in the synthesis of phosphinothricin analogs, which are potential inhibitors of glutamine synthetase. Glutamine synthetase is an enzyme that plays a crucial role in the metabolism of nitrogenous compounds in cells, and its inhibition can lead to the disruption of cellular processes, making it a target for the development of drugs against various diseases, including cancer.
In the preparation of phosphinothricin analogs, (2-Aminoethyl)phosphinic acid serves as a building block, providing the necessary structural elements for the formation of these bioactive compounds. By incorporating this compound into the synthesis process, researchers can design and develop novel analogs with improved potency, selectivity, and pharmacological properties, ultimately leading to the discovery of new therapeutic agents with potential applications in the treatment of various diseases.
Furthermore, the versatility of (2-Aminoethyl)phosphinic acid allows for the exploration of its potential applications in other areas of pharmaceutical research, such as the development of enzyme inhibitors, antimicrobial agents, and other bioactive molecules. Its unique structure and reactivity make it a valuable tool for the design and synthesis of new compounds with diverse biological activities, contributing to the advancement of drug discovery and development efforts.
Check Digit Verification of cas no
The CAS Registry Mumber 85618-16-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,5,6,1 and 8 respectively; the second part has 2 digits, 1 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 85618-16:
(7*8)+(6*5)+(5*6)+(4*1)+(3*8)+(2*1)+(1*6)=152
152 % 10 = 2
So 85618-16-2 is a valid CAS Registry Number.
85618-16-2Relevant articles and documents
Synthesis of P,N-heterocycles from ω-amino-H-phosphinates: Conformationally restricted α-amino acid analogs
Queffelec, Clemence,Ribiere, Patrice,Montchamp, Jean-Luc
supporting information; experimental part, p. 8987 - 8991 (2009/04/11)
(Chemical Equation Presented) P,N-Heterocycles (3-hydroxy-1,3- azaphospholane and 3-hydroxy-1,3-azaphosphorinane-3-oxide) are synthesized in moderate yield from readily available ω-amino-H-phosphinates and aldehydes or ketones via an intramolecular Kabachnik-Fields reaction. The products are conformationally restricted phosphinic analogs of α-amino acids. The multigram-scale syntheses of the H2N(CH2) nPO2H2 phosphinic precursors (n = 1, 2, 3) and some derivatives are also described.
DIETHOXYMETHYLPHOSPHONITES AND PHOSPHINATES. INTERMEDIATES FOR THE SYNTHESIS OF α,β- AND γ-AMINOALKYLPHOSPHONOUS ACIDS
Dingwall, J. G.,Ehrenfreund, J.,Hall, R. G.
, p. 3787 - 3808 (2007/10/02)
New building blocks for the synthesis of functional alkyl phosphonous acids are described.Diethoxymethylphosphonites and phosphinates are readily prepared and undergo reactions typical of phosphites and phosphonates.The products are stable to chemical transformations, readily handled and purified, and easily transformed to the phosphonous acids.
