85650-55-1

Basic information

• Product Name: cis-5-chloro-2,3,3a,12b-tetrahydro-2-methyl-1H-dibenz[2,3:6,7]oxepino[4,5-c]pyrrole maleate
• Synonyms: cis-5-Chloro-2,3,3a,12b-tetrahydro-2-methyl-1H-dibenz(2,3:6,7)oxepino(4,5-c)pyrrole maleate
• CAS NO: 85650-55-1
• Molecular Formula: C₂₁H₂₀ClNO₅
• Molecular Weight: 401.8402
• EINECS: 288-063-2
• Mol File: 85650-55-1.mol
• Article Data: 25

Chemical Properties

• Boiling Point: 563.1°C at 760 mmHg
• Flash Point: 294.4°C
• Vapor Pressure: 1.62E-13mmHg at 25°C
• CAS DataBase Reference: cis-5-chloro-2,3,3a,12b-tetrahydro-2-methyl-1H-dibenz[2,3:6,7]oxepino[4,5-c]pyrrole maleate(CAS DataBase Reference)
• NIST Chemistry Reference: cis-5-chloro-2,3,3a,12b-tetrahydro-2-methyl-1H-dibenz[2,3:6,7]oxepino[4,5-c]pyrrole maleate(85650-55-1)
• EPA Substance Registry System: cis-5-chloro-2,3,3a,12b-tetrahydro-2-methyl-1H-dibenz[2,3:6,7]oxepino[4,5-c]pyrrole maleate(85650-55-1)

Safety Data

• Hazardous Substances Data: 85650-55-1(Hazardous Substances Data)

Upstream product

• 110-16-7 maleic acid 
• 165890-26-6 C₁₇H₁₄ClNO₂ 
• 65621-78-5 asenapine 
• 6915-18-0 2-butenedioic acid 
• 934996-80-2 5-chloro-2-methyl-2,3,3a,12b-tetrahydro-1H-dibenzo[2,3:6,7]oxepino[4,5-c]pyrrole-1-one 
• 1180843-77-9 trans-11-chloro-2,3,3a,12b-tetrahydro-2-methyl-1H-dibenz(2,3:6,7)oxepino(4,5-c)pyrrol-1-one 
• 912356-09-3 trans-5-chloro-2,3,3a,12b-tetrahydro-2-methyl-1H-dibenz(2,3:6,7)oxepino(4,5-c)pyrrol-1-one 
• 65621-78-5 trans-5-chloro-2-methyl-2,3,3a,12b-tetrahydro-1H-dibenz[2,3:6,7]oxepino[4,5-c]pyrrole 
• 65621-78-5 (3aRS,12bRS)-rel-5-chloro-2,3,3a,12b-tetrahydro-2-methyl-1H-dibenz[2,3:6,7]oxepino[4,5-c]pyrrole 
• 934996-79-9 5-chloro-2-methyl-2,3-dihydro-1H-dibenzo[2,3:6,7]oxepino [4,5-c]pyrrole-1-one 
• 912356-09-3 cis 5-chloro-2-methyl-2,3,3a,12b-tetrahydro-1H-dibenzo[2,3:6,7]oxepino[4,5-c]pyrrole-1-one 
• 3433-80-5 1-Bromo-2-bromomethyl-benzene 
• 63909-55-7 diethyl 2-bromobenzylphosphonate 
• 1431973-29-3 C₁₉H₁₉BrN₂O₄ 

Downstream Products

• 65621-78-5 asenapine 
• 65621-78-5 asenapine 

Relevant articles and documents

Method for preparing the maleic acid Arab League fills evenly that

The invention discloses a preparation method of high-purity asenapine maleate. The preparation method comprises the following steps: by taking an asenapine free alkali crude product and a asenapine maleate crude product as an initial raw material, reacting the asenapine free alkali crude product with an organic acid to generate salt or carrying out alkalifying dissociation on the asenapine maleate crude product to asenapine free alkali to be reacted with the organic acid to generate salt so as to obtain asenapine para-benzyl benzyl; crystallizing, filtering and carrying out alkalifying dissociation to obtain asenapine free alkali; then reacting the product obtained from the former step with maleic acid to obtain asenapine maleate; and crystallizing and filtering. The preparation method of high purity asenapine maleate is novel in process route, mild in process condition and simple to operate, and an acceptable product with the purity greater than or equal to 99% can be obtained by just one time without repeatedly recrystallizing operations. Meanwhile, the preparation method further improves the reaction yield, lowers the production cost, is suitable for being applied to industrial production on a large scale, and has good practical value and social and economic benefits.

Amide activation by TMSCl: Reduction of amides to amines by LiAlH 4 under mild conditions

An expeditious and practical method for the reduction of amides to amines is reported. The method consists of activation of amides with TMSCl followed by reduction with LiAlH4. Various amides/lactams including hindered amides and secondary amides gave the corresponding amines in good to excellent yields. This novel protocol has a wide substrate scope and shows good functional group tolerance with high stereoretention.

IMPROVED PROCESS FOR THE PREPARATION OF ASENAPINE MALEATE

The present invention relates to a process for the preparation of Asenapine maleate with an avoiding column chromatography by use of DBN or DBA.