86060-89-1 Usage
General Description
FMOC-ILE-OPFP, scientific name Fmoc-Ile-OPfp, is a chemical compound used mainly in solid phase peptide synthesis (SPPS). It is an amino acid derivative which belongs to the Fmoc amino acids/ peptides product category. FMOC-ILE-OPFP is an important chemical reagent that is essential in the synthesis of peptide chains. The two main components of this chemical are the Fmoc group (9-fluorenylmethyloxycarbonyl group), which conducts amino protection during peptide synthesis, and ILE (Isoleucine), which is one of the necessary amino acids in humans, involved in various protein formations. The FMOC group of the FMOC-ILE-OPFP provides necessary amino protection that aids in correct peptide synthesis, whereas the ILE (Isoleucine) part of the chemical is used in numerous protein formations. This chemical also makes it feasible to create a number of biologically active peptides and extrapolate the growth of peptide-based drugs.
Check Digit Verification of cas no
The CAS Registry Mumber 86060-89-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,6,0,6 and 0 respectively; the second part has 2 digits, 8 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 86060-89:
(7*8)+(6*6)+(5*0)+(4*6)+(3*0)+(2*8)+(1*9)=141
141 % 10 = 1
So 86060-89-1 is a valid CAS Registry Number.
InChI:InChI=1/C27H22F5NO4/c1-3-13(2)24(26(34)37-25-22(31)20(29)19(28)21(30)23(25)32)33-27(35)36-12-18-16-10-6-4-8-14(16)15-9-5-7-11-17(15)18/h4-11,13,18,24H,3,12H2,1-2H3,(H,33,35)/t13-,24-/m0/s1
86060-89-1Relevant articles and documents
A new facile one-pot preparation of pentafluorophenyl (Pfp) and 3,4-dihydro-4-oxo-1,2,3-benzotriazine-3-yl (Dhbt) esters of Fmoc amino acids
Jacobsen, Mogens Havsteen,Buchardt, Ole,Engdahl, Tom,Holm, Arne
, p. 6199 - 6202 (2007/10/02)
A new one-pot procedure for the preparation of pentafluorophenyl and 3,4-dihydro-4-oxo-1,2,3-benzotriazine-3-yl esters of Nα-9-fluorenylmethyloxycarbonyl amino acids bearing no side chain protecting groups is described. The method gives the desired activated esters in high yield and purity without use of the highly allergenic DCC.
9-Fluorenylmethyl Pentafluorophenyl Carbonate as a Useful Reagent for the Preparation of N-9-Fluorenylmethyloxycarbonylamino Acids and their Pentafluorophenyl Esters
Schoen, Istvan,Kisfaludy, Lajos
, p. 303 - 305 (2007/10/02)
9-Fluorenylmethyl pentafluorophenyl carbonate is a useful reagent for the efficient, side reaction-free introduction of N-9-fluorenylmethyloxycarbonyl protecting group into amino acids and for the subsequent preparation of their pentafluorophenyl esters.Some new compounds of both types are described.
