862574-89-8

Basic information

• Product Name: 1-(1,3-BENZODIOXOL-5-YL)CYCLOPROPANECARBOXYLIC ACID
• Synonyms: 1-(1,3-BENZODIOXOL-5-YL)CYCLOPROPANECARBOXYLIC ACID;1-(BENZO[D][1,3]DIOXOL-6-YL)CYCLOPROPANECARBOXYLIC ACID;UKRORGSYN-BB BBV-223328;1-(Benzodioxol-5-yl)cyclopropanecarboxylic acid;1-(benzo[d][1,3]dioxol-5-yl)cyclopropanecarboxylic acid;Cyclopropanecarboxylic acid, 1-(1,3-benzodioxol-5-yl)-
• CAS NO: 862574-89-8
• Molecular Formula: C₁₁H₁₀O₄
• Molecular Weight: 206.2
• Mol File: 862574-89-8.mol
• Article Data: 15

Chemical Properties

• Appearance: /
• Refractive Index: 1.644
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 1-(1,3-BENZODIOXOL-5-YL)CYCLOPROPANECARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(1,3-BENZODIOXOL-5-YL)CYCLOPROPANECARBOXYLIC ACID(862574-89-8)
• EPA Substance Registry System: 1-(1,3-BENZODIOXOL-5-YL)CYCLOPROPANECARBOXYLIC ACID(862574-89-8)

Safety Data

• Hazardous Substances Data: 862574-89-8(Hazardous Substances Data)

Usage

Description

1-(1,3-Benzodioxol-5-yl)cyclopropanecarboxylic acid is an organic compound characterized by the presence of a cyclopropane ring fused with a benzodioxole moiety. It possesses a carboxylic acid functional group, which allows for various chemical reactions and modifications. This unique structure endows it with potential applications in the synthesis of pharmaceuticals and other organic compounds.

Uses

Used in Pharmaceutical Industry:
1-(1,3-Benzodioxol-5-yl)cyclopropanecarboxylic acid is used as a reagent in the preparation of N-pyridinyl carboxamide derivatives. These derivatives act as modulators of ATP-binding cassette transporters, which play a crucial role in the transport of various molecules across extraand intra-cellular membranes. Modulating these transporters can have therapeutic benefits in treating a range of diseases, including cancer and multidrug resistance.

InChI:InChI=1/C11H10O4/c12-10(13)11(3-4-11)7-1-2-8-9(5-7)15-6-14-8/h1-2,5H,3-4,6H2,(H,12,13)

Upstream product

• 4439-02-5 3,4-methylenedioxyphenylacetonitrile 
• 33522-14-4 1-benzo[1,3]dioxol-5-yl-cyclopropanecarbonitrile 
• 2635-13-4 1,2-(methylenedioxy)-4-bromobenzene 
• 94839-07-3 3,4-(methylenedioxy)-benzeneboronic acid 
• 107-04-0 1-Bromo-2-chloroethane 
• 4421-09-4 piperonylonitrile 

Relevant articles and documents

Chiral Bidentate Boryl Ligand Enabled Iridium-Catalyzed Enantioselective C(sp3)-H Borylation of Cyclopropanes

We herein report an Ir-catalyzed enantioselective C(sp3)-H borylation of cyclopropanecarboxamides using a chiral bidentate boryl ligand for the first time. A variety of substrates with α-quaternary carbon centers could be compatible in this reaction to provide β-borylated products with good to excellent enantioselectivities. We have also demonstrated that the borylated products can be used as versatile precursors engaging in stereospecific transformations of C-B bonds, including the synthesis of a bioactive compound Levomilnacipran.

N-{[2-(PIPERIDIN-1-YL)PHENYL](PHENYL)METHYL}-2-(3-OXO-3,4-DIHYDRO-2H-1,4-BENZOXA ZIN-7-YL)ACETAMIDE DERIVATIVES AND RELATED COMPOUNDS AS ROR-GAMMA MODULATORS FOR TREATING AUTOIMMUNE DISEASES

The present invention provides e.g. N-{[2-(piperidin-1-yl)phenyl] (phenyl)methyl}-2-(3-oxo-3,4-dihydro-2H-1,4-benzoxazin-7-yl)acetamide derivatives and related compounds as ROR-gamma modulators for treating e.g. autoimmune diseases, autoimmune-related diseases, inflammatory diseases, metabolic diseases, fibrotic diseases or cholestatic diseases, such as e.g. arthitis and asthma.

Compositions for Treatment of Cystic Fibrosis and Other Chronic Diseases

The present invention relates to pharmaceutical compositions comprising an inhibitor of epithelial sodium channel activity in combination with at least one ABC Transporter modulator compound of Formula A, Formula B, Formula C, or Formula D. The invention also relates to pharmaceutical formulations thereof, and to methods of using such compositions in the treatment of CFTR mediated diseases, particularly cystic fibrosis using the pharmaceutical combination compositions.