864248-43-1

Basic information

• Product Name: 2-Pyridinecarboxylic acid, 4-(2-fluoro-4-nitrophenoxy)-, methyl ester
• CAS NO: 864248-43-1
• Molecular Formula: C13H9FN2O5
• Molecular Weight: 292.223
• Mol File: 864248-43-1.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 2-Pyridinecarboxylic acid, 4-(2-fluoro-4-nitrophenoxy)-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Pyridinecarboxylic acid, 4-(2-fluoro-4-nitrophenoxy)-, methyl ester(864248-43-1)
• EPA Substance Registry System: 2-Pyridinecarboxylic acid, 4-(2-fluoro-4-nitrophenoxy)-, methyl ester(864248-43-1)

Safety Data

• Hazardous Substances Data: 864248-43-1(Hazardous Substances Data)

Upstream product

• 24484-93-3 4-Chloro-pyridine-2-carboxylic acid methyl ester 
• 403-19-0 2-fluoro-4-nitrophenol 
• 98-98-6 2-Picolinic acid 
• 5470-22-4 4-chloropicolinic acid 

Relevant articles and documents

Discovery of novel diaryl urea derivatives bearing a triazole moiety as potential antitumor agents

Herein, we report a novel series of diaryl urea derivatives bearing a triazole moiety, from which potent antitumor agents have been identified. With a modified triazole, most compounds showed high level activity in both cellular and enzymatic assays, accompanied with a suitable ClogD7.4 value. The most active compound, 13i, effectively suppressed proliferation of HT-29, H460 and MDA-MB-231 cancer cells, with IC50 values of 0.90, 0.85 and 1.54 μM, respectively. Compound 13i also exhibited significant inhibition of tyrosine kinases including c-Kit, RET and FLT3. Furthermore, compound 13i could obviously induce apoptosis of HT-29 cells in a concentration-dependent manner. The study of structure-activity relationships also revealed that a hydrophilic tail at the 4-position of the triazole was crucial for high activity of the compound.

NOVEL PYRIDINE DERIVATIVE AND PYRIMIDINE DERIVATIVE (3)

A compound represented by the following formula, a salt thereof or a hydrate of the foregoing has an excellent hepatocyte growth factor receptor (HGFR) inhibitory activity, and exhibits anti-tumor activity, angiogenesis inhibitory activity and cancer metastasis inhibitory activity. [R1 represents a 3- to 10-membered non-aromatic heterocyclic group or the like; R2 and R3 represent hydrogen; R4, R5, R6, and R7 may be the same or different and each represents hydrogen, halogen, C1-6 alkyl or the like; R8 represents hydrogen or the like; R9 represents a 3- to 10-membered non-aromatic heterocyclic group or the like; n represents an integer of 1 or 2; X represents -CH=, nitrogen or the like.]