864943-63-5 Usage
General Description
(1-Aminomethyl-cyclohexyl)-carbamic acid tert-butyl ester is a chemical compound with the molecular formula C11H21N3O2. It is a carbamate ester, which is a type of chemical compound used in various industries including pharmaceuticals, insecticides, and as a precursor in organic synthesis. This particular compound is a tert-butyl ester derivative of (1-aminomethyl-cyclohexyl)-carbamic acid, which is commonly used as a reagent in chemical reactions. The tert-butyl ester group is a common protecting group in organic synthesis, used to temporarily mask a functional group in a molecule. (1-AMINOMETHYL-CYCLOHEXYL)-CARBAMIC ACID TERT-BUTYL ESTER is an important building block in the synthesis of various organic compounds and is used in research and development in the pharmaceutical and agrochemical industries.
Check Digit Verification of cas no
The CAS Registry Mumber 864943-63-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,6,4,9,4 and 3 respectively; the second part has 2 digits, 6 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 864943-63:
(8*8)+(7*6)+(6*4)+(5*9)+(4*4)+(3*3)+(2*6)+(1*3)=215
215 % 10 = 5
So 864943-63-5 is a valid CAS Registry Number.
InChI:InChI=1/C12H24N2O2/c1-11(2,3)16-10(15)14-12(9-13)7-5-4-6-8-12/h4-9,13H2,1-3H3,(H,14,15)
864943-63-5Relevant articles and documents
Novel potent inhibitors of hepatitis C virus (HCV) NS3 protease with cyclic sulfonyl P3 cappings
Chen, Kevin X.,Vibulbhan, Bancha,Yang, Weiying,Nair, Latha G.,Tong, Xiao,Cheng, Kuo-Chi,Njoroge, F. George
body text, p. 1105 - 1109 (2009/08/07)
Extensive SAR studies of the P3 capping group led to the discovery of a series of potent inhibitors with sultam and cyclic sulfonyl urea moieties as the P3 capping. The bicyclic thiophene-sultam or phenyl-sultam cappings were selected for further SAR development. Modification at the P3 side chain determined that the tert-butyl group was the best choice at that position. Optimization of P1 residue significantly improved potency and selectivity. The combination of optimal moieties at all positions led to the discovery of compound 33. This compound had the best overall profile in potency and PK profile: excellent Ki* of 5.3 nM and activity in replicon (EC90) of 80 nM, extremely high selectivity of 6100, and a good rat PO AUC of 1.43 μM h.
