864943-64-6

Basic information

• Product Name: C₂₀H₂₆N₂O₄
• Synonyms: C₂₀H₂₆N₂O₄
• CAS NO: 864943-64-6
• Molecular Weight: 358.437
• Mol File: 864943-64-6.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: C₂₀H₂₆N₂O₄(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₀H₂₆N₂O₄(864943-64-6)
• EPA Substance Registry System: C₂₀H₂₆N₂O₄(864943-64-6)

Safety Data

• Hazardous Substances Data: 864943-64-6(Hazardous Substances Data)

Upstream product

• 864943-63-5 C₁₂H₂₄N₂O₂ 
• 22509-74-6 N-ethoxycarbonylphthalimide 
• 136918-14-4 phthalimide 
• 187610-67-9 1-[1-(tert-butoxycarbonylamino)cyclohexyl]methanol 

Downstream Products

• 864943-63-5 C₁₂H₂₄N₂O₂ 

Relevant articles and documents

Novel potent inhibitors of hepatitis C virus (HCV) NS3 protease with cyclic sulfonyl P3 cappings

Extensive SAR studies of the P3 capping group led to the discovery of a series of potent inhibitors with sultam and cyclic sulfonyl urea moieties as the P3 capping. The bicyclic thiophene-sultam or phenyl-sultam cappings were selected for further SAR development. Modification at the P3 side chain determined that the tert-butyl group was the best choice at that position. Optimization of P1 residue significantly improved potency and selectivity. The combination of optimal moieties at all positions led to the discovery of compound 33. This compound had the best overall profile in potency and PK profile: excellent Ki* of 5.3 nM and activity in replicon (EC90) of 80 nM, extremely high selectivity of 6100, and a good rat PO AUC of 1.43 μM h.

NOVEL KETOAMIDES WITH CYCLIC P4'S AS INHIBITORS OF NS3 SERINE PROTEASE OF HEPATITIS C VIRUS

The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of using them to treat disorders associated with the HCV protease.