865234-02-2 Usage
Description
Methyl 3-(4-hydroxyphenyl)hex-4-ynoate is a chemical compound with the molecular formula C13H12O3. It is an ester formed by the reaction of an alcohol with an organic acid, resulting in the elimination of a water molecule. Methyl3-(4-hydroxyphenyl)hex-4-ynoate contains a hexynoate group, which is an organic functional group with a triple bond between two carbon atoms, and a 4-hydroxyphenyl group, indicating the presence of a hydroxyl group attached to a phenyl ring. Methyl 3-(4-hydroxyphenyl)hex-4-ynoate has potential applications in various industries, including pharmaceuticals, cosmetics, and organic synthesis.
Uses
Used in Pharmaceutical Industry:
Methyl 3-(4-hydroxyphenyl)hex-4-ynoate is used as a pharmaceutical intermediate for the synthesis of various drugs and active pharmaceutical ingredients. Its unique structure and functional groups make it a valuable building block in the development of new medications.
Used in Cosmetics Industry:
Methyl 3-(4-hydroxyphenyl)hex-4-ynoate is used as an active ingredient in cosmetics for its potential antioxidant and anti-aging properties. The presence of the hydroxyl group attached to the phenyl ring may contribute to its ability to protect the skin from oxidative stress and promote collagen synthesis.
Used in Organic Synthesis:
Methyl 3-(4-hydroxyphenyl)hex-4-ynoate is used as a key intermediate in the synthesis of various organic compounds, including specialty chemicals, dyes, and other complex molecules. Its unique structure and reactivity make it a versatile building block in organic chemistry.
Check Digit Verification of cas no
The CAS Registry Mumber 865234-02-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,6,5,2,3 and 4 respectively; the second part has 2 digits, 0 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 865234-02:
(8*8)+(7*6)+(6*5)+(5*2)+(4*3)+(3*4)+(2*0)+(1*2)=172
172 % 10 = 2
So 865234-02-2 is a valid CAS Registry Number.
865234-02-2Relevant articles and documents
Discovery of novel potent GPR40 agonists containing imidazo[1,2-a]pyridine core as antidiabetic agents
Ye, Zhiwen,Liu, Chunxia,Zou, Feng,Cai, Yan,Chen, Bin,Zou, Yuxing,Mo, Jiaxian,Han, Ting,Huang, Wenlong,Qiu, Qianqian,Qian, Hai
, (2020/06/19)
Free fatty acid receptor 1 (FFA1 or GPR40) has been studied for many years as a target for the treatment of type 2 diabetes mellitus. In order to increase potency and reduce hepatotoxicity, a series of novel compounds containing imidazo[1,2-a]pyridine sca
AGONISTS OF GPR40
-
, (2012/02/05)
The present invention relates to compounds that have the ability to modulate the activity of GPR40 and are there-fore useful in the treatment of GPR40 related disorders. In addition the invention relates to the compounds, methods for their preparation, pharmaceutical compositions containing the compounds and the uses of these compounds in the treatment of certain disorders related to GPR40 activity.
3-Substituted 3-(4-aryloxyaryl)-propanoic acids as GPR40 agonists
Walsh, Shawn P.,Severino, Alexandra,Zhou, Changyou,He, Jiafang,Liang, Gui-Bai,Tan, Carina P.,Cao, Jin,Eiermann, George J.,Xu, Ling,Salituro, Gino,Howard, Andrew D.,Mills, Sander G.,Yang, Lihu
, p. 3390 - 3394 (2011/06/24)
The design, synthesis, and structure-activity relationship (SAR) for a series of β-substituted 3-(4-aryloxyaryl)propanoic acid GPR40 agonists is described. Systematic replacement of the pendant aryloxy group led to identification of potent GPR40 agonists. In order to identify candidates suitable for in vivo validation of the target, serum shifted potency and pharmacokinetic properties were determined for several compounds. Finally, further profiling of compound 7 is presented, including demonstration of enhanced glucose tolerance in an in vivo mouse model.
