866685-33-8

Basic information

• Product Name: 3-bromo-5-(3-fluorophenylethynyl)-pyridine
• Synonyms: 3-bromo-5-(3-fluorophenylethynyl)-pyridine
• CAS NO: 866685-33-8
• Molecular Weight: 276.108
• Mol File: 866685-33-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-bromo-5-(3-fluorophenylethynyl)-pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 3-bromo-5-(3-fluorophenylethynyl)-pyridine(866685-33-8)
• EPA Substance Registry System: 3-bromo-5-(3-fluorophenylethynyl)-pyridine(866685-33-8)

Safety Data

• Hazardous Substances Data: 866685-33-8(Hazardous Substances Data)

Upstream product

• 625-92-3 3,5-dibromopyridine 
• 2561-17-3 1-ethynyl-3-fluoro-benzene 

Relevant articles and documents

PYRIDYL DERIVATIVES AND THEIR USE AS MGLU5 RECEPTOR ANTAGONISTS

The present invention is directed toward pyridyl derivatives of formula (I) as antagonists of the mGlu5 receptor. As such the compounds may be useful for treatment or prevention of disorders remedied by antagonism of the mGlu5 receptor, wherein Ar is phenyl or napthyl each of which may be substituted by one or more C1-C4 alkyl, C1-C4 alkoxy, C1-C5 acyl, halo, amino, nitro, cyano, hydroxy, C1-C5 acylamino, C1-C4 alkylsulfonylamino, mono-, di- or trifluorinated C1-C3 alkyl, substituents which may be the same or different and may bear a CONH2, CONHCH3, CON(CH3)2, CO2H, CO2CH3, OCF3, CH2NHCOCH3, CH2NH2, CH2N(CH3)2, CH2CN, CH2OH, CH2NHSO2CH3, CH2N(CH3)(CH2)2 CN, CH2N(CH3)CH(CH3)2, CH2NHCH(CH3)2, CH2NH(CH2)2CH3, CH2NHCO2R4, CH2NHCH2CH3, CH2NHCH3 NHCOC(CH3)2, or N(S(O)2CH3)2 substituent; R1 is hydrogen, halo, R4, CN, C(NOH)R3, C(NO-R4)R3, (CH)2CO2R4 , (CH2)n OR3 , COR3 , CF3,SR4 , S(O)R4, S(O)2R4, COCH2CO2R3 , NHSO2R4 , NHCOR3, C(NOR3)NH2, CH2OCOR3,(CH2)n NH2, CON(CH3)2 (CH2)nNHCO2R4 , CO2R3, CONH2, CSNH2, C(NH)NHOR3, (CH2)nN(CH3)2, or CONHNHCOR3; R2 is 1,2-ethenediyl or 1,2-ethynediyl; R3 is hydrogen or C1-C4 alkyl; R4 is C1-C4 alkyl; and n is 0, 1, 2,3 or 4; or a pharmaceutically acceptable salt thereof, or an N-oxide thereof.