86826-93-9

Basic information

• Product Name: 2-(2-bromo-5-methoxyphenyl)acetic acid
• Synonyms: 2-(2-bromo-5-methoxyphenyl)acetic acid
• CAS NO: 86826-93-9
• Molecular Formula: C₉H₉BrO₃
• Molecular Weight: 245.06996
• Mol File: 86826-93-9.mol
• Article Data: 19

Chemical Properties

• Melting Point: 115 °C
• Boiling Point: 362.0±27.0 °C(Predicted)
• Appearance: /
• Density: 1.560±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 3.94±0.10(Predicted)
• CAS DataBase Reference: 2-(2-bromo-5-methoxyphenyl)acetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-bromo-5-methoxyphenyl)acetic acid(86826-93-9)
• EPA Substance Registry System: 2-(2-bromo-5-methoxyphenyl)acetic acid(86826-93-9)

Safety Data

• Hazardous Substances Data: 86826-93-9(Hazardous Substances Data)

Usage

General Description

2-(2-bromo-5-methoxyphenyl)acetic acid is a chemical compound that features prominently in the field of organic chemistry. It incorporates elements such as bromine and methoxy groups attached to a phenyl ring, with an acetic acid component attached. 2-(2-bromo-5-methoxyphenyl)acetic acid may serve as a key building block in the synthesis of more complex chemical products and might play a role in various research investigations exploring different chemical reactions. Its properties will be influenced by factors like the bromine's electronegativity and the methoxy group and acetic acid's potential for hydrophilic interaction. More information such as its specific synthetic preparation processes, physical properties, and potential applications would be obtained through advanced chemistry literature or studies.

Upstream product

• 19614-12-1 2-bromo-5-methoxybenzyl bromide 
• 27060-75-9 4-bromo-3-methylanisole 
• 860758-95-8 (2-bromo-5-methoxy-phenyl)-pyruvic acid 
• 7722-84-1 dihydrogen peroxide 
• 27387-23-1 5-methoxy-2-bromophenylacetonitrile 
• 1798-09-0 m-methoxyphenylacetic acid 

Downstream Products

• 1350840-07-1 2-(2-bromo-5-methoxyphenyl)-N-methoxyacetamide 

Relevant articles and documents

Copper-Catalyzed Lactamization of (E)-2-(2-Bromophenyl)-3-arylacrylamides for the Synthesis of (E)-3-Arylideneindolin-2-ones

A copper-catalyzed, ligand-free intramolecular C-N coupling of (E)-2-(2-bromophenyl)-3-arylacrylamides has been developed. This protocol provides an efficient and practical synthetic route for the biologically important (E)-3-arylideneindolin-2-ones from

Simple analogues of natural product chelerythrine: Discovery of a novel anticholinesterase 2-phenylisoquinolin-2-ium scaffold with excellent potency against acetylcholinesterase

As simple analogues of the natural compound chelerythrine, a novel anti-cholinesterase 2-phenylisoquinolin-2-ium scaffold was designed by structure imitation. The activity evaluation led to the discovery of seven compounds with potent anti-acetylcholinesterase activity with IC50 values of ≤0.72 μM, superior to chelerythrine and standard drugs galantamine. Particularly, compound 8y showed the excellent dual acetylcholinesterase-butyrylcholinesterase inhibition activity, superior to rivastigmine, a dual cholinesterase inhibitor drug. Furthermore, the compounds displayed a competitive anti-acetylcholinesterase mechanism with the substrate and low cytotoxicity. Molecular docking showed that the isoquinoline moiety is embedded in a cavity surrounded by four aromatic residues of acetylcholinesterase by the π-π action. Structure-activity relationship showed that the p-substituents on the C-ring can dramatically improve the anti-acetylcholinesterase activity, while 8-OMe can increase the activity against the two cholinesterases simultaneously. Thus, the title compounds emerged as promising lead compounds for the development of novel cholinesterase inhibitor agents.

Chiral Magnesium Bisphosphate-Catalyzed Asymmetric Double C(sp3)-H Bond Functionalization Based on Sequential Hydride Shift/Cyclization Process

Described herein is a chiral magnesium bisphosphate-catalyzed asymmetric double C(sp3)-H bond functionalization triggered by a sequential hydride shift/cyclization process. This reaction consists of stereoselective domino C(sp3)-H bond functionalization: (1) a highly enantio- and diastereoselective C(sp3)-H bond functionalization by chiral magnesium bisphosphate (first [1,5]-hydride shift), and (2) a highly diastereoselective C(sp3)-H bond functionalization by an achiral catalyst (Yb(OTf)3, second [1,5]-hydride shift).