86884-90-4Relevant articles and documents
A short and efficient asymmetric synthesis of (-)-frontalin, (-)-exo-isobrevicomin and a volatile contributor of beer-aroma
Singh, Surendra,Guiry, Patrick J.
, p. 5701 - 5706 (2010)
The natural products, (-)-frontalin and (+)-exo-isobrevicomin were synthesized employing Sharpless asymmetric epoxidation and ZrCl 4-catalyzed intramolecular acetalization as the key steps. (-)-Frontalin was synthesized in three steps with a 61
Asymmetric total synthesis of naturally occurring spirocyclic tetranorsesquiterpenoid lanceolactone A
Acharyya, Ranjan Kumar,Nanda, Samik
, p. 5027 - 5035 (2018/07/25)
Asymmetric total synthesis of naturally occurring γ-butenolide containing [4.4]spiro-tetrahydrofuran lanceolactone A has been reported in the present work. Bimetallic ("Pd-Cu") cascade cyclization was the crucial reaction employed for the construction of the γ-butenolide framework of the natural product. Subsequently, iodocyclization and reductive deiodination through a transfer hydrogenation reaction were applied to access the target molecule in an efficient manner.
Using an asymmetric flow reactor sharples
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Paragraph 0042-0046, (2019/05/21)
PROBLEM TO BE SOLVED: To provide a method for efficiently progressing a Sharpless asymmetric epoxidation even without adding molecular sieves. SOLUTION: The method for producing an optically active epoxyalcohol compound includes mixing an allyl alcohol compound, a titanium tetraalkoxide in a catalytic amount, an optically active tartaric acid ester in a catalytic amount, and an oxidizing agent, in a solvent by using a flow-type reactor (flow reactor). The oxidizing agent is preferably tert-butyl hydroperoxide or cumene hydroperoxide. COPYRIGHT: (C)2013,JPOandINPIT