513-42-8Relevant articles and documents
Tailoring Polyethers for Post-polymerization Functionalization by Cross Metathesis
Morrison, Stephen D.,Liskamp, Rob M. J.,Prunet, Jo?lle
, p. 2253 - 2256 (2018)
Olefin cross metathesis is reported for the first time to attach small molecules to a range of novel polyethers with a poly(ethylene glycol) backbone and pendent alkene groups, allowing for a loading of up to one compound per monomer unit. These polymers are tailored to prevent the occurrence of self metathesis (reaction of the polymer with itself) by varying the substitution on the pendent alkenes, thus steering their reactivity toward olefin cross metathesis. Efficient functionalization has been observed for a range of coupling partners as a proof of concept for the use of olefin metathesis to graft small and larger molecules to polyethers for drug delivery. This approach also paves the way for the use of olefin cross metathesis as an efficient method to functionalize a wide variety of polymers with pendent olefin groups.
Scheschukow
, (1884)
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Currell,Fry
, p. 4377 (1956)
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Regiospecific Synthesis of Calcium-Independent Daptomycin Antibiotics using a Chemoenzymatic Method
Mupparapu, Nagaraju,Lin, Yu-Hsin Cindy,Kim, Tae Ho,Elshahawi, Sherif I.
supporting information, p. 4176 - 4182 (2021/02/01)
Daptomycin (DAP) is a calcium (Ca2+)-dependent FDA-approved antibiotic drug for the treatment of Gram-positive infections. It possesses a complex pharmacophore hampering derivatization and/or synthesis of analogues. To mimic the Ca2+-binding effect, we used a chemoenzymatic approach to modify the tryptophan (Trp) residue of DAP and synthesize kinetically characterized and structurally elucidated regiospecific Trp-modified DAP analogues. We demonstrated that the modified DAPs are several times more active than the parent molecule against antibiotic-susceptible and antibiotic-resistant Gram-positive bacteria. Strikingly, and in contrast to the parent molecule, the DAP derivatives do not rely on calcium or any additional elements for activity.
PROCESS FOR PREPARING 2-METHALLYL ALCOHOL
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Paragraph 0049-0066, (2021/06/09)
Step 1: reacting a basic aqueous solution 2 - with 1 methallyl chloride in the presence of a catalyst. 1-th step of separating the oil layer and the water layer by adding an NH 2 aqueous solution to the reacted product in Step 2. The method 2 - wherein 3 metaallyl alcohol is obtained from the down stream by separating the oil layer into a down stream and an upstream using a boiling point difference. And. The catalyst is an ionic liquid (Ionic liquid) and relates to a method for producing 2 -methallyl alcohol. To the present invention, 2 - metaallyl alcohol having high selectivity and high yield can be provided.