869366-03-0

Basic information

• Product Name: [3-[4-Chloro-2-(2,6-difluorobenzoyl)phenyl]prop-2-ynyl]carbamic acid tert-butyl ester
• Synonyms: [3-[4-Chloro-2-(2,6-difluorobenzoyl)phenyl]prop-2-ynyl]carbamic acid tert-butyl ester;tert-Butyl (3-(4-chloro-2-(2,6-difluorobenzoyl)-phenyl)prop-2-yn-1-yl)carbamate
• CAS NO: 869366-03-0
• Molecular Formula: C₂₁H₁₈ClF₂NO₃
• Molecular Weight: 405.83
• Product Categories: API intermediates
• Mol File: 869366-03-0.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: [3-[4-Chloro-2-(2,6-difluorobenzoyl)phenyl]prop-2-ynyl]carbamic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: [3-[4-Chloro-2-(2,6-difluorobenzoyl)phenyl]prop-2-ynyl]carbamic acid tert-butyl ester(869366-03-0)
• EPA Substance Registry System: [3-[4-Chloro-2-(2,6-difluorobenzoyl)phenyl]prop-2-ynyl]carbamic acid tert-butyl ester(869366-03-0)

Safety Data

• Hazardous Substances Data: 869366-03-0(Hazardous Substances Data)

Usage

General Description

[3-[4-Chloro-2-(2,6-difluorobenzoyl)phenyl]prop-2-ynyl]carbamic acid tert-butyl ester is a chemical compound with the molecular formula C20H16ClF2NO3. It is a carbamate ester with a prop-2-ynyl group and a tert-butyl ester group. [3-[4-Chloro-2-(2,6-difluorobenzoyl)phenyl]prop-2-ynyl]carbamic acid tert-butyl ester is used in pharmaceutical research and may have potential applications in the development of new drugs. It is important to handle and use this chemical with caution, following proper safety protocols and guidelines to avoid any potential hazards.

Upstream product

• 28910-83-0 (2-amino-5-chlorophenyl)-(2,6-difluorophenyl)methanone 
• 18437-66-6 N-(t-butoxycarbonyl)-4-chloroaniline 
• 869365-92-4 tert-butyl (4-chloro-2-(2,6-difluorobenzoyl)phenyl)carbamate 
• 869365-97-9 (5-chloro-2-iodophenyl)(2,6-difluorophenyl)methanone 
• 92136-39-5 N-tert-Butoxycarbonyl-1-amino-3-propyne 

Downstream Products

• 869363-13-3 4-{[9-chloro-7-(2,6-difluorophenyl)-5H-pyrimido[5,4-d][2]benzazepin-2-yl]amino}benzoic acid 
• 1393381-45-7 tert-butyl (1-(2-(4-((9-chloro-7-(2,6-difluorophenyl)-5H-benzo[c]pyrimido[4,5-e]azepin-2-yl)amino)benzamido)ethyl)piperidin-4-yl)carbamate 
• 1393381-46-8 N-(2-(4-aminopiperidin-1-yl)ethyl)-4-((9-chloro-7-(2,6-difluorophenyl)-5H-benzo[c]pyrimido[4,5-e]azepin-2-yl)amino)benzamide 
• 869366-10-9 8-chloro-4-[(dimethylamino)methylene]-1-(2,6-difluorophenyl)-3,4-dihydro-5H-2-benzazepin-5-one 
• 869366-09-6 8-chloro-1-(2,6-difluorophenyl)-3,4-dihydrobenzo[c]azepin-5-one 

Relevant articles and documents

MLN8054 and Alisertib (MLN8237): Discovery of Selective Oral Aurora A Inhibitors

The Aurora kinases are essential for cell mitosis, and the dysregulation of Aurora A and B have been linked to the etiology of human cancers. Investigational agents MLN8054 (8) and alisertib (MLN8237, 10) have been identified as high affinity, selective,

Compounds and methods for inhibiting mitotic progression

This invention relates to compounds and methods for the treatment of cancer. In particular, the invention provides compounds that inhibit Aurora kinase, pharmaceutical compositions comprising the compounds, and methods of using the compounds for the treat