869366-10-9

Basic information

• Product Name: (E)-8-chloro-1-(2,6-difluorophenyl)-4-((diMethylaMino)Methylene)-3H-benzo[c]azepin-5(4H)-one
• Synonyms: (E)-8-chloro-1-(2,6-difluorophenyl)-4-((diMethylaMino)Methylene)-3H-benzo[c]azepin-5(4H)-one
• CAS NO: 869366-10-9
• Molecular Formula: C₁₉H₁₅ClF₂N₂O
• Molecular Weight: 360.7850064
• Mol File: 869366-10-9.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (E)-8-chloro-1-(2,6-difluorophenyl)-4-((diMethylaMino)Methylene)-3H-benzo[c]azepin-5(4H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-8-chloro-1-(2,6-difluorophenyl)-4-((diMethylaMino)Methylene)-3H-benzo[c]azepin-5(4H)-one(869366-10-9)
• EPA Substance Registry System: (E)-8-chloro-1-(2,6-difluorophenyl)-4-((diMethylaMino)Methylene)-3H-benzo[c]azepin-5(4H)-one(869366-10-9)

Safety Data

• Hazardous Substances Data: 869366-10-9(Hazardous Substances Data)

Usage

Description

(E)-8-chloro-1-(2,6-difluorophenyl)-4-((diMethylaMino)Methylene)-3H-benzo[c]azepin-5(4H)-one is a complex organic chemical compound belonging to the benzodiazepine class. It features a molecular formula of C20H15ClF2N2O and is characterized by its unique structure, which includes a chlorine atom at the 8th position, a 2,6-difluorophenyl group, and a diMethylaMino methylene bridge. (E)-8-chloro-1-(2,6-difluorophenyl)-4-((diMethylaMino)Methylene)-3H-benzo[c]azepin-5(4H)-one is primarily utilized as a research reagent and intermediate in organic synthesis, with potential pharmaceutical applications in the treatment of neurological and psychiatric disorders.

Uses

Used in Pharmaceutical Research:
(E)-8-chloro-1-(2,6-difluorophenyl)-4-((diMethylaMino)Methylene)-3H-benzo[c]azepin-5(4H)-one is used as a research reagent for the development of new drugs targeting neurological and psychiatric disorders. Its unique chemical structure and properties make it a valuable tool in the design and synthesis of novel therapeutic agents.
Used in Organic Synthesis:
In the field of organic chemistry, (E)-8-chloro-1-(2,6-difluorophenyl)-4-((diMethylaMino)Methylene)-3H-benzo[c]azepin-5(4H)-one serves as an intermediate in the synthesis of various complex organic molecules. Its versatile structure allows for further functionalization and modification, enabling the creation of a wide range of compounds with diverse applications.
Used in Scientific Studies:
(E)-8-chloro-1-(2,6-difluorophenyl)-4-((diMethylaMino)Methylene)-3H-benzo[c]azepin-5(4H)-one is also employed in scientific research to investigate its pharmacological properties and potential therapeutic uses. Studies on (E)-8-chloro-1-(2,6-difluorophenyl)-4-((diMethylaMino)Methylene)-3H-benzo[c]azepin-5(4H)-one contribute to the understanding of its interactions with biological systems and may lead to the discovery of new treatment options for various conditions.

Upstream product

• 869366-03-0 tert-butyl (3-(4-chloro-2-(2,6-difluorobenzoyl)phenyl)prop-2-yn-1-yl)carbamate 
• 869365-97-9 (5-chloro-2-iodophenyl)(2,6-difluorophenyl)methanone 
• 28910-83-0 (2-amino-5-chlorophenyl)-(2,6-difluorophenyl)methanone 
• 869366-09-6 8-chloro-1-(2,6-difluorophenyl)-3,4-dihydrobenzo[c]azepin-5-one 
• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 

Downstream Products

• 869363-13-3 4-{[9-chloro-7-(2,6-difluorophenyl)-5H-pyrimido[5,4-d][2]benzazepin-2-yl]amino}benzoic acid 
• 1203588-98-0 C₂₄⁽¹⁴⁾CH₁₄ClF₂N₄O₂^(1-)*Na⁽¹⁺⁾ 
• 1203588-97-9 sodium 4-[[2-⁽¹⁴⁾C-9-chloro-7-(2,6-difluorophenyl)-5H-pyrimido[5,4-d][2]benzazepin-2-yl]amino]-benzoate 
• 1203589-00-7 4-[[1,3-di⁽¹⁵⁾N-9-chloro-7-(2,6-difluorophenyl)-5H-pyrimido[5,4-d][2]benzazepin-2-yl]amino]-2,3,5,6-tetradeutero-benzoic acid 

Relevant articles and documents

MLN8054 and Alisertib (MLN8237): Discovery of Selective Oral Aurora A Inhibitors

The Aurora kinases are essential for cell mitosis, and the dysregulation of Aurora A and B have been linked to the etiology of human cancers. Investigational agents MLN8054 (8) and alisertib (MLN8237, 10) have been identified as high affinity, selective,