869494-40-6Relevant articles and documents
Design and synthesis of peptidomimetic severe acute respiratory syndrome chymotrypsin-like protease inhibitors
Ghosh, Arun K.,Xi, Kai,Ratia, Kiira,Santarsiero, Bernard D.,Fu, Wentao,Harcourt, Brian H.,Rota, Paul A.,Baker, Susan C.,Johnson, Michael E.,Mesecar, Andrew D.
, p. 6767 - 6771 (2007/10/03)
Design, synthesis, and biological evaluation of peptidomimetic severe acute respiratory syndrome chymotrypsin-like protease (SARS-3CLpro) inhibitors for severe acute respiratory syndrome coronavirus (SARS-CoV) are described. These inhibitors exhibited antiviral activity against SARS-CoV in infected cells in the micromolar range. An X-ray crystal structure of our lead inhibitor (4) bound to SARS-3CLpro provided important drug-design templates for the design of small-molecule inhibitors.