87066-93-1

Basic information

• Product Name: (2-Diethylamino-phenyl)-methanol
• Synonyms: (2-Diethylamino-phenyl)-methanol
• CAS NO: 87066-93-1
• Molecular Weight: 179.262
• Mol File: 87066-93-1.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (2-Diethylamino-phenyl)-methanol(CAS DataBase Reference)
• NIST Chemistry Reference: (2-Diethylamino-phenyl)-methanol(87066-93-1)
• EPA Substance Registry System: (2-Diethylamino-phenyl)-methanol(87066-93-1)

Safety Data

• Hazardous Substances Data: 87066-93-1(Hazardous Substances Data)

Upstream product

• 87-25-2 2-ethoxycarbonylaniline 
• 394-35-4 methyl 2-fluorobenzoate 
• 91563-72-3 N,N-diethylanthranilic acid methyl ester 
• 94023-76-4 ethyl 2-(N,N-diethylamino)benzoate 
• 728041-69-8 N-acetyl-N-ethyl-anthranilic acid ethyl ester 

Downstream Products

• 113805-35-9 (2-Chloromethyl-phenyl)-diethyl-amine 
• 112562-79-5 2-(2-Dibutylamino-phenyl)-thiazolidine-3-carbothioic acid methylamide; compound with sulfuric acid 
• 112562-77-3 2-(2-Diethylamino-phenyl)-thiazolidine-3-carbothioic acid methylamide; compound with sulfuric acid 
• 1026967-41-8 Diethyl-[2-(1-pyridin-2-ylmethyl-1,4,5,6-tetrahydro-cyclopentaimidazol-2-ylsulfanylmethyl)-phenyl]-amine 
• 1027262-54-9 Diethyl-[2-(1-pyridin-4-yl-1,4,5,6-tetrahydro-cyclopentaimidazol-2-ylsulfanylmethyl)-phenyl]-amine 
• 117323-79-2 Diethyl-[2-(1-pyridin-2-yl-1,4,5,6-tetrahydro-cyclopentaimidazol-2-ylsulfanylmethyl)-phenyl]-amine 
• 117323-02-1 Diethyl-{2-[1-(3-methoxy-pyridin-2-yl)-1H-imidazol-2-ylsulfanylmethyl]-phenyl}-amine 

Relevant articles and documents

2-[(2-Aminobenzyl)sulfinyl]-1-(2-pyridyl)-1,4,5,6- tetrahydrocyclopent[d]imidazoles as a novel class of gastric H+/K+-ATPase inhibitors

Substituted 2-sulfinylimidazoles were synthesized and investigated as potential inhibitors of gastric H+/K+-ATPase. The 4,5-unsubstituted imidazole series 6-11 and the 1,4,5,6-tetrahydrocyclopent[d]imidazole series 12 were found to be potent inhibitors of the acid secretory enzyme H+/K+- ATPase. Structure-activity relationships indicate that the substitution of 2- pyridyl groups at the 1-position of the imidazole moiety combined with (2- aminobenzyl)sulfinyl groups at the 2-position leads to highly active compounds with a favorable chemical stability. Other substitution patterns in the imidazole moiety result in reducing biological activities. 2-[(2- Aminobenzyl)sulfinyl]-1-[2-(3-methylpyridyl)]-1,4,5,6- tetrahydrocyclopent[d]imidazole (12h, T-776) was selected for further development as a potential clinical candidate. Extensive study on the acid degradation of 12h indicates a mechanism of action different from that of omeprazole, the first H+/K+-ATPase inhibitor introduced to the market.

Synthesis of 2-phenylthiazolidine derivatives as cardiotonic agents. I. 2-Phenylthiazolidine-3-thiocarboxamides.

-