870962-68-8

Basic information

• Product Name: 2-Butenamide, N-[4-[(4-chloro-2,5-dimethoxyphenyl)amino]-7-ethoxy-6-quinazolinyl]-4-( dimethylamino)-, (2E)-
• CAS NO: 870962-68-8
• Molecular Formula: C24H28ClN5O4
• Molecular Weight: 485.97
• Mol File: 870962-68-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-Butenamide, N-[4-[(4-chloro-2,5-dimethoxyphenyl)amino]-7-ethoxy-6-quinazolinyl]-4-( dimethylamino)-, (2E)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Butenamide, N-[4-[(4-chloro-2,5-dimethoxyphenyl)amino]-7-ethoxy-6-quinazolinyl]-4-( dimethylamino)-, (2E)-(870962-68-8)
• EPA Substance Registry System: 2-Butenamide, N-[4-[(4-chloro-2,5-dimethoxyphenyl)amino]-7-ethoxy-6-quinazolinyl]-4-( dimethylamino)-, (2E)-(870962-68-8)

Safety Data

• Hazardous Substances Data: 870962-68-8(Hazardous Substances Data)

Upstream product

• 6358-64-1 4-chloro-2,5-dimethoxy-aniline 
• 936954-11-9 N-(4-chloro-2,5-dimethoxyphenyl)-7-ethoxy-6-nitroquinazolin-4-amine 
• 936954-10-8 4-chloro-7-ethoxy-6-nitroquinazoline 
• 936954-09-5 7-ethoxy-6-nitroquinazolin-4-ol 
• 162012-69-3 7-fluoro-6-nitro-4-hydroxyquinazoline 
• 936954-12-0 N⁴-(4-chloro-2,5-dimethoxyphenyl)-7-ethoxyquinazoline-4,6-diamine 
• 1130155-48-4 (E)-4-(dimethylamino)-2-butenoic acid hydrochloride 

Downstream Products

• 870962-70-2 C₂₂H₂₂ClN₅O₄ 

Relevant articles and documents

Dual irreversible kinase inhibitors: Quinazoline-based inhibitors incorporating two independent reactive centers with each targeting different cysteine residues in the kinase domains of EGFR and VEGFR-2

A series of 4-dimethylamino-but-2-enoic acid [4-(3,6-dioxo-cyclohexa-1,4-dienylamino)-7-ethoxy-quinazolin-6-yl]-amide derivatives were prepared. These compounds have two independent reactive centers and were designed to function as dual irreversible inhib