87184-99-4

Basic information

• Product Name: 4-(TERT-BUTYLDIMETHYLSILYL)-OXY-1-BUTAN&
• Synonyms: 4-(TERT-BUTYLDIMETHYLSILYL)-OXY-1-BUTAN&;1-tert-ButyldiMethylsilyl-4-hydroxybutane;4-[[(1,1-DiMethylethyl)diMethylsilyl]oxy]-1-butanol;4-tert-ButyldiMethylsiloxy-1-butanol, 97%;4-(tert-Butyldimethylsilyl)oxy-1-butanol 97%;4-[Tert-Butyl(Dimethyl)Silyl]Oxybutan-1-Ol;4-tert-Butyldimethylsilyloxybutanol;4-(tert-Butyldimethylsiloxy)butanol300374-99-6
• CAS NO: 87184-99-4
• Molecular Formula: C₁₀H₂₄O₂Si
• Molecular Weight: 204.384
• Product Categories: Alcohols;C9 to C30;Oxygen Compounds;Aliphatics
• Mol File: 87184-99-4.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 63-66 °C0.3 mm Hg(lit.)
• Flash Point: 222 °C
• Appearance: /
• Density: 0.888 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.0128mmHg at 25°C
• Refractive Index: n20/D 1.4390(lit.)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 15.07±0.10(Predicted)
• Water Solubility: Slightly Soluble in water.(2.0 g/L) (25°C). Soluble in Dichloromethane, Ethyl Acetate, Methanol
• CAS DataBase Reference: 4-(TERT-BUTYLDIMETHYLSILYL)-OXY-1-BUTAN&(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(TERT-BUTYLDIMETHYLSILYL)-OXY-1-BUTAN&(87184-99-4)
• EPA Substance Registry System: 4-(TERT-BUTYLDIMETHYLSILYL)-OXY-1-BUTAN&(87184-99-4)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 87184-99-4(Hazardous Substances Data)

Usage

Description

4-(TERT-BUTYLDIMETHYLSILYL)-OXY-1-BUTAN&, also known as 4-(Dimethyl-tert-Butylsilyloxy)butan-1-ol, is a colorless oil compound with the CAS number 87184-99-4. It is primarily used in organic synthesis due to its unique chemical properties.

Uses

Used in Organic Synthesis:
4-(TERT-BUTYLDIMETHYLSILYL)-OXY-1-BUTAN& is used as a synthetic intermediate for the production of various organic compounds. Its chemical properties, such as being a colorless oil, make it suitable for use in the synthesis of a wide range of organic molecules.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 4-(TERT-BUTYLDIMETHYLSILYL)-OXY-1-BUTAN& is used as a building block for the development of new drugs. Its unique structure allows it to be incorporated into the design of novel pharmaceutical compounds, potentially leading to the discovery of new therapeutic agents.
Used in Chemical Research:
4-(TERT-BUTYLDIMETHYLSILYL)-OXY-1-BUTAN& is also utilized in chemical research for studying the properties and reactions of silyl ethers. Its reactivity and stability make it an interesting subject for research in the field of organosilicon chemistry.
Overall, 4-(TERT-BUTYLDIMETHYLSILYL)-OXY-1-BUTAN& is a versatile compound with applications in various industries, including organic synthesis, pharmaceuticals, and chemical research. Its unique properties and potential for use in the development of new compounds make it an important tool in the field of chemistry.

InChI:InChI=1/C10H24O2Si/c1-10(2,3)13(4,5)12-9-7-6-8-11/h11H,6-9H2,1-5H3

Upstream product

• 117785-64-5 1-tert-butyldimethylsilyloxy-4-triethylsilyloxybutane 
• 1333925-48-6 allyl 4-(tert-butyldimethylsilyloxy)butylcarbonate 
• 75-33-2 2-propanethiol 
• 105966-46-9 [4-(benzyloxy)butoxy](tert-butyl)dimethylsilane 
• 87184-81-4 4-(tert-butyldimethylsilanyloxy)butanal 
• 104-94-9 4-methoxy-aniline 
• 69171-63-7 4-(tert-butyldimethylsilyloxy)butyric acid methyl ester 

Downstream Products

• 92511-12-1 1-{[dimethyl(1,1-dimethylethyl)silyl]oxy}-4-iodobutane 
• 87184-81-4 4-(tert-butyldimethylsilanyloxy)butanal 
• 110-63-4 Butane-1,4-diol 
• 1361250-48-7 (2S/R,8R)-11-(tert-butyldimethylsilyloxy)-8-hydroxyundec-6-yn-2-yl benzoate 
• 1215493-87-0 (E)-tert-butyl 2-(6-(tert-butyldimethylsilyloxy)hex-3-enamido)phenylcarbamate 
• 1616562-07-2 tert-butyldimethyl((4-(3-phenylpropoxy)hex-5-en-1-yl)oxy)silane 
• 874915-14-7 N-benzyl-4-((tert-butyldimethylsilyl)oxy)butan-1-amine 
• 197219-12-8 (4Z)-8-(tert-butyldiphenylsilyloxy)-4-octen-1-ol 
• 864758-39-4 3-{2-[4-(tert-butyl-dimethyl-silanyloxy)-butyryl]-phenyl}-acrylic acid ethyl ester 
• 909036-18-6 3-{2-[4-(tert-butyl-dimethyl-silanyloxy)-butyryl]-phenyl}-acrylic acid ethyl ester 
• 864758-38-3 4-(tert-butyl-dimethyl-silanyloxy)-1-(2-hydroxymethyl-phenyl)-butan-1-ol 

Relevant articles and documents

A mild ligand-free iron-catalyzed liberation of alcohols from allylcarbonates

Different from most carbonates the allyloxy carbonyl protecting group can be cleaved under neutral conditions using metal catalysis. However, most of the catalysts employed to date are based upon precious metals. Herein we present two protocols for the mild Fe-catalyzed liberation of alcohols from allylcarbonates that are characterized by broad functional group tolerance and exclusive chemoselectivity.

N,N′-carbonyldiimidazole-mediated cyclization of amino alcohols to substituted azetidines and other N-heterocycles

Amino alcohols are important synthons for N-heterocycles. We have developed an efficient method to activate hydroxyl groups, which avoids the use of toxic reagents and tolerates a wide variety of functional groups. Our strategy has been applied to the syn

Facile cleavage of triethylsilyl (TES) ethers using o-lodoxybenzoic acid (IBX) without affecting tert-butyldimethylsilyl (TBS) ethers

(matrix presented) In DMSO cleavage of triethylsilyl (TES) ethers by o-iodoxybenzoic acid (IBX) was significantly faster than cleavage of tert-butyldimethylsilyl (TBS) ethers or further oxidation into carbonyl compounds. In most cases, TES protecting groups be removed in good to excellent yields within 1 h, whereas similar TBS protecting groups remained intact under the same conditions. The procedure also could be adapted for direct one-pot conversion of TES ethers into carbonyl compounds.