872181-59-4

Basic information

• Product Name: 1-(3,5-DIFLUOROPHENYL)ETHANOL
• Synonyms: 3,5-DIFLUOROPHENYLMETHYLCARBINOL;1-(3,5-DIFLUOROPHENYL)ETHAN-1-OL;1-(3,5-DIFLUOROPHENYL)ETHANOL;(3,5-Difluorophenyl)methylcarbinol, 1-(3,5-Difluorophenyl)ethan-1-ol;3,5-Difluoro-alpha-methylbenzyl alcohol 97%;3,5-Difluoro-alpha-methylbenzylalcohol97%
• CAS NO: 872181-59-4
• Molecular Formula: C₈H₈F₂O
• Molecular Weight: 158.15
• Mol File: 872181-59-4.mol
• Article Data: 10

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-(3,5-DIFLUOROPHENYL)ETHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(3,5-DIFLUOROPHENYL)ETHANOL(872181-59-4)
• EPA Substance Registry System: 1-(3,5-DIFLUOROPHENYL)ETHANOL(872181-59-4)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 872181-59-4(Hazardous Substances Data)

Usage

General Description

1-(3,5-Difluorophenyl)ethanol is a chemical compound with the molecular formula C8H8F2O. It is a colorless liquid with a molecular weight of 158.15 g/mol. 1-(3,5-DIFLUOROPHENYL)ETHANOL is commonly used in the pharmaceutical industry as an intermediate for the synthesis of various drug molecules. It has also been studied for its potential antimicrobial and antifungal properties. Additionally, 1-(3,5-Difluorophenyl)ethanol has been used in research as a starting material for the preparation of other organic compounds. It is important to handle this chemical with care, as it may pose health hazards if not used properly.

Upstream product

• 123577-99-1 3′,5′-difluoroacetophenone 
• 117358-52-8 1-ethyl-3,5-difluorobenzene 
• 32085-88-4 3,5-difluorobenzaldehyde 
• 75-16-1 methylmagnesium bromide 

Downstream Products

• 321318-29-0 (R)-1-(3,5-difluorophenyl)ethan-1-amine 
• 1620014-24-5 N-{4-[(3S,5R)-3-amino-5-(trifluoromethyl)piperidin-1-yl]-7-hydroxy-6,7-dihydro-5H-cyclopenta[b]pyridin-3-yl}-6-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]-5-fluoropyridine-2-carboxamide 
• 1620014-27-8 4-[(3S,5R)-3-[(tert-butoxycarbonyl)amino]-5-(trifluoromethyl)piperidin-1-yl]-3-[({6-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]-5-fluoropyridin-2-yl}carbonyl)amino]-6,7-dihydro-5H-cyclopenta[b]pyridin-7-yl acetate 
• 1620013-79-7 N-{4-[(3R,4R,5S)-3-amino-4-hydroxy-5-methylpiperidin-1-yl]-2,3-dihydrofuro[2,3-b]pyridin-5-yl}-6-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]-5-fluoropyridine-2-carboxamide 
• 1620013-80-0 tert-butyl ((3R,4R,5S)-4-{[tert-butyl(dimethyl)silyl]oxy}-1-{5-[({6-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]-5-fluoropyridin-2-yl}carbonyl)amino]-2,3-dihydrofuro[2,3-b]pyridin-4-yl}-5-methylpiperidin-3-yl)carbamate 
• 1355011-40-3 6-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]-5-fluoropyridine-2-carboxylic acid 
• 1355011-39-0 methyl 6-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]-5-fluoropyridine-2-carboxylate 
• 1063733-77-6 2-(3,5-difluorophenoxy)propan-2-ol 
• 123577-99-1 3′,5′-difluoroacetophenone 
• 1620013-87-7 N-{4-[(3S,5R)-3-amino-5-methylpiperidin-1-yl]-7-hydroxy-6,7-dihydro-5H-cyclopenta[b]pyridin-3-yl}-6-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]-5-fluoropyridine-2-carboxamide 
• 1620013-89-9 tert-butyl ((3S,5R)-1-{3-[({6-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]-5-fluoropyridin-2-yl}carbonyl)amino]-7-hydroxy-6,7-dihydro-5H-cyclopenta[b]pyridin-4-yl}-5-methylpiperidin-3-yl)carbamate 
• 1620013-88-8 4-{(3S,5R)-3-[(tert-butoxycarbonyl)amino]-5-methylpiperidin-1-yl}-3-[({6-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]-5-fluoropyridin-2-yl}carbonyl)amino]-6,7-dihydro-5H-cyclopenta[b]pyridin-7-yl acetate 
• 1586045-19-3 1-(3,5-difluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)ethanol 
• 1586040-47-2 N-(5-((2S,5R,6R)-5-amino-6-fluorooxepan-2-yl)-1-methyl-1H-pyrazol-4-yl)-6-(2,6-difluoro-4-(1-hydroxyethyl)phenyl)-5-fluoropicolinamide 

Relevant articles and documents

Chromoselective Photocatalysis Enables Stereocomplementary Biocatalytic Pathways**

Controlling the selectivity of a chemical reaction with external stimuli is common in thermal processes, but rare in visible-light photocatalysis. Here we show that the redox potential of a carbon nitride photocatalyst (CN-OA-m) can be tuned by changing the irradiation wavelength to generate electron holes with different oxidation potentials. This tuning was the key to realizing photo-chemo-enzymatic cascades that give either the (S)- or the (R)-enantiomer of phenylethanol. In combination with an unspecific peroxygenase from Agrocybe aegerita, green light irradiation of CN-OA-m led to the enantioselective hydroxylation of ethylbenzene to (R)-1-phenylethanol (99 % ee). In contrast, blue light irradiation triggered the photocatalytic oxidation of ethylbenzene to acetophenone, which in turn was enantioselectively reduced with an alcohol dehydrogenase from Rhodococcus ruber to form (S)-1-phenylethanol (93 % ee).

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THIAZOLECARBOXAMIDES AND PYRIDINECARBOXAMIDE COMPOUNDS USEFUL AS PIM KINASE INHIBITORS

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