123577-99-1 Usage
Description
3',5'-Difluoroacetophenone, also known as 1-(3,5-difluorophenyl)ethanone, is a fluorinated acetophenone characterized by its white to light yellow crystal powder form.
Uses
Used in Pharmaceutical Synthesis:
3',5'-Difluoroacetophenone is used as a key intermediate in the synthesis of various pharmaceutical compounds for their potential therapeutic applications.
Used in Organic Chemistry:
3',5'-Difluoroacetophenone is used as a reagent in organic chemistry for the preparation of various organic compounds, including:
1. (E)-3-(4-(1,5,9-trithia-13-azacyclohexadecan-13-yl)-phenyl)-1-(3,5-difluorophenyl)prop-2-en-1-one: 3',5'-Difluoroacetophenone is synthesized using 3',5'-Difluoroacetophenone as a starting material, which may have potential applications in medicinal chemistry or as a functional organic molecule.
2. 1,3,5-triarylpyrazoline fluorophores containing a 16-membered thiazacrown ligand: These fluorophores are synthesized using 3',5'-Difluoroacetophenone, and they can be utilized in the development of fluorescent probes or sensors.
3. (±)-fluorinated-1-(3-morpholin-4-yl-phenyl)ethylamine: This fluorinated amine derivative is synthesized using 3',5'-Difluoroacetophenone, which may have potential applications in the synthesis of pharmaceuticals or agrochemicals.
4. (E)-1-(3,5-difluorophenyl)-3-(2,4-dimethoxyphenyl) prop-2-en-1-one: 3',5'-Difluoroacetophenone is synthesized using 3',5'-Difluoroacetophenone and can be used as a building block in the synthesis of more complex organic molecules.
5. 1-(3,5-difluorophenyl)-4,4,4-trifluorobutane-1,3-dione: 3',5'-Difluoroacetophenone is synthesized using 3',5'-Difluoroacetophenone and can be used as a precursor for the synthesis of various organic compounds with potential applications in different industries.
Check Digit Verification of cas no
The CAS Registry Mumber 123577-99-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,3,5,7 and 7 respectively; the second part has 2 digits, 9 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 123577-99:
(8*1)+(7*2)+(6*3)+(5*5)+(4*7)+(3*7)+(2*9)+(1*9)=141
141 % 10 = 1
So 123577-99-1 is a valid CAS Registry Number.
InChI:InChI=1/C8H6F2O/c1-5(11)6-2-7(9)4-8(10)3-6/h2-4H,1H3
123577-99-1Relevant articles and documents
An efficient approach for enhancing the catalytic activity of Ni-MOF-74: Via a relay catalyst system for the selective oxidation of benzylic C-H bonds under mild conditions
Guo, Changyan,Zhang, Yonghong,Zhang, Yi,Wang, Jide
supporting information, p. 3701 - 3704 (2018/04/17)
Although nickel-based materials exhibit similar catalytic activity to palladium in organic synthesis, the selective oxidation of inert C-H bonds in the absence of other co-catalysts remains a largely unsolved challenge. This paper introduces a facile and efficient approach for enhancing the catalytic activity of Ni-MOF-74 with [bmim]Br via a relay catalysis strategy, which is excellent for the selective oxidation of benzylic C-H bonds. Notably, the catalyst recycling and scale up experiments demonstrated the practicability of the protocol. This method combines the catalytic advantages of MOFs and ionic liquids (ILs), and provides an insight into oxidation reactions by cheap and efficient Ni-based catalysts.
THIAZOLECARBOXAMIDES AND PYRIDINECARBOXAMIDE COMPOUNDS USEFUL AS PIM KINASE INHIBITORS
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Paragraph 1098; 1099, (2014/07/23)
The present disclosure describes thiazole and pyridine carboxamide derivatives, their compositions and methods of use. The compounds inhibit the activity of the Pim kinases and are useful in the treatment of diseases related to the activity of Pim kinases including, e.g., cancer and other diseases.
One-pot one-step deracemization of amines using ω-transaminases
Shin, Giyoung,Mathew, Sam,Shon, Minsu,Kim, Byung-Gee,Yun, Hyungdon
, p. 8629 - 8631 (2013/09/23)
In this study, we developed a one-pot one-step deracemization method for the production of various enantiomerically pure amines using two opposite enantioselective ω-TAs. Using this method, various aromatic amines were successfully converted to their (R)-forms (>99%) with good conversion.
