875846-26-7

Basic information

• Product Name: 2-(4-nitrophenyl)benzothiazole-6-carbonyl chloride
• Synonyms: 2-(4-nitrophenyl)benzothiazole-6-carbonyl chloride
• CAS NO: 875846-26-7
• Molecular Weight: 318.74
• Mol File: 875846-26-7.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-(4-nitrophenyl)benzothiazole-6-carbonyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-nitrophenyl)benzothiazole-6-carbonyl chloride(875846-26-7)
• EPA Substance Registry System: 2-(4-nitrophenyl)benzothiazole-6-carbonyl chloride(875846-26-7)

Safety Data

• Hazardous Substances Data: 875846-26-7(Hazardous Substances Data)

Upstream product

• 65644-51-1 2-(4-nitrophenyl)-1,3-benzothiazole-6-carboxylic acid 
• 122-04-3 4-nitro-benzoyl chloride 
• 23451-96-9 2-amino-5-methylthiophenol 
• 488722-57-2 6-methyl-2-(4'-nitrophenyl)-1,3-benzothiazole 
• 14543-45-4 4-amino-3-mercaptobenzoic acid 

Downstream Products

• 73302-00-8 4-(6-methyl-[2,6';2',6'']terbenzothiazol-2''-yl)-aniline 
• 95-22-7 4-(6-methyl-[2,6']bibenzothiazolyl-2'-yl)-aniline 
• 934704-66-2 C₂₀H₁₂FN₃S₂ 
• 934704-65-1 C₂₀H₁₂ClN₃S₂ 
• 909904-76-3 C₂₀H₁₃N₃S₂ 
• 909904-75-2 C₂₀H₁₁N₃O₂S₂ 
• 934704-64-0 C₂₀H₁₀(OCH₃)N₃O₂S₂ 
• 934704-63-9 C₂₀H₁₀FN₃O₂S₂ 
• 934704-62-8 C₂₀H₁₀ClN₃O₂S₂ 
• 855266-37-4 6-methyl-2'-(4-nitro-phenyl)-[2,6']bibenzothiazolyl 

Relevant articles and documents

Dibenzothiazoles as novel amyloid-imaging agents

Novel dibenzothiazole derivatives were synthesized and evaluated as amyloid-imaging agents. In vitro quantitative binding studies using AD brain tissue homogenates showed that the dibenzothiazole derivatives displayed high binding affinities with Ki values in the nanomolar range (6.8-36 nM). These derivatives are relatively lipophilic with partition coefficients (logP oct) in the range of 1.25-3.05. Preliminary structure-activity relationship studies indicated dibenzothiazole derivatives bearing electron-donating groups exhibited higher binding affinities than those bearing electron-withdrawing groups. A lead compound was selected for its high binding affinity and radiolabeled with [125I] through direct radioiodination using sodium [125I] iodide in the presence of Chloramine T. The radioligand (4-[2,6′]dibenzothiazolyl-2′-yl-2-[125I]-phenylamine) displayed moderate lipophilicity (logP oct, 2.70), very good brain uptake (3.71 ± 0.63% ID/g at 2 min after iv injection in mice), and rapid washout from normal brains (0.78% and 0.43% ID/g at 30 and 60 min, respectively). These studies indicated that lipophilic dibenzothiazole derivatives represent a promising pharmacophore for the development of novel amyloid-imaging agents for potential application in Alzheimer's disease and related neurodegenerative disorders.