878207-91-1

Basic information

• Product Name: 2-(Methoxycarbonyl)-3-Methylpyridine 1-oxide
• Synonyms: 2-(Methoxycarbonyl)-3-Methylpyridine 1-oxide;3-Methyl-2-pyridinecarboxylic acid 1-oxide methyl ester;Methyl 3-methyl-2-pyridinecarboxylate 1-oxide;methyl 3-methyl-1-oxido-pyridin-1-ium-2-carboxylate
• CAS NO: 878207-91-1
• Molecular Formula: C₈H₉NO₃
• Molecular Weight: 167.16196
• Mol File: 878207-91-1.mol
• Article Data: 13

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-(Methoxycarbonyl)-3-Methylpyridine 1-oxide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(Methoxycarbonyl)-3-Methylpyridine 1-oxide(878207-91-1)
• EPA Substance Registry System: 2-(Methoxycarbonyl)-3-Methylpyridine 1-oxide(878207-91-1)

Safety Data

• Hazardous Substances Data: 878207-91-1(Hazardous Substances Data)

Usage

Common use

Reagent in organic synthesis, building block in pharmaceutical industry

Known for

Potential use as a radical scavenger and antioxidant

Potential applications

Treating neurodegenerative diseases and oxidative stress-related disorders

Used in production

Pharmaceutical intermediates, agrochemicals
Versatile and important compound in organic chemistry.

Upstream product

• 59718-84-2 3-methyl-pyridine-2-carboxylic acid methyl ester 

Downstream Products

• 878207-92-2 methyl 6-chloro-3-methyl-pyridine-2-carboxylate 
• 1400664-29-0 C₂₇H₂₉N₃O₄ 
• 1400664-24-5 C₂₇H₂₉N₃O₄ 
• 1400664-30-3 C₂₆H₂₆ClN₃O₃ 
• 1400664-31-4 C₂₆H₂₆ClN₃O₃ 
• 1400664-26-7 C₂₆H₂₆ClN₃O₃ 
• 1400664-32-5 C₂₆H₂₆FN₃O₃ 
• 1400664-27-8 C₂₆H₂₆FN₃O₃ 
• 1400664-17-6 C₂₇H₂₆F₃N₃O₃ 
• 1400664-35-8 C₂₇H₂₆N₄O₃ 
• 1400664-07-4 C₂₇H₂₉N₃O₃ 
• 1400664-23-4 C₂₇H₂₉N₃O₃ 
• 1400664-09-6 C₂₈H₃₁N₃O₃ 
• 1400664-10-9 C₂₈H₃₁N₃O₃ 

Relevant articles and documents

From Pyridine- N-oxides to 2-Functionalized Pyridines through Pyridyl Phosphonium Salts: An Umpolung Strategy

The reactions of pyridine-N-oxides with Ph3P under the developed conditions provide an unprecedented route to (pyridine-2-yl)phosphonium salts. Upon activation with DABCO, these salts readily serve as functionalized 2-pyridyl nucleophile equivalents. This umpolung strategy allows for the selective C2 functionalization of the pyridine ring with electrophiles, avoiding the generation and use of unstable organometallic reagents. The protocol operates at ambient temperature and tolerates sensitive functional groups, enabling the synthesis of otherwise challenging compounds.

NRF2 REGULATORS

Provided are aryl analogs，pharmaceutical compositions containing them and their use as NRF2 regulators.

ALKYNYL ALCOHOLS AND METHODS OF USE

The invention relates to compounds of Formula (0): wherein A1-A8, R4 and R5 each has the meaning as described herein. Compounds of Formula (0) and pharmaceutical compositions thereof are useful in the treatment of diseases and disorders in which undesired or over-activation of NF-kB signaling is observed.