878285-14-4

Basic information

• Product Name: 2,5-difluoro-4-methylaniline
• Synonyms: 2,5-difluoro-4-methylaniline;2,5-difluoro-4-aminotoluene
• CAS NO: 878285-14-4
• Molecular Formula: C7H7F2N
• Molecular Weight: 143.1339864
• Mol File: 878285-14-4.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• CAS DataBase Reference: 2,5-difluoro-4-methylaniline(CAS DataBase Reference)
• NIST Chemistry Reference: 2,5-difluoro-4-methylaniline(878285-14-4)
• EPA Substance Registry System: 2,5-difluoro-4-methylaniline(878285-14-4)

Safety Data

• Hazardous Substances Data: 878285-14-4(Hazardous Substances Data)

Usage

General Description

2,5-difluoro-4-methylaniline is a chemical compound with the molecular formula C7H7F2N. It is a derivative of aniline, featuring two fluorine atoms and a methyl group attached to the aromatic ring. 2,5-difluoro-4-methylaniline is commonly used in organic synthesis as a building block for the production of various pharmaceuticals, dyes, and agrochemicals. It is known for its strong nucleophilic properties and ability to undergo several types of chemical reactions, making it a versatile intermediate in the manufacturing of diverse organic compounds. Additionally, 2,5-difluoro-4-methylaniline is a hazardous substance and should be handled with care due to its potential health and environmental risks.

Upstream product

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Relevant articles and documents

Preparation method of 2,4,5-trifluorophenylacetic acid

The invention belongs to the technical field of preparation of drug intermediates, and discloses a preparation method of 2,4,5-trifluorophenylacetic acid, wherein the preparation method comprises the steps: step 1, reacting raw materials, a quaternary ammonium salt catalyst, sulfolane and potassium fluoride to obtain a first intermediate; step 2, carrying out hydrogenation catalytic reaction on the first intermediate to obtain a second intermediate; step 3, carrying out salt forming reaction on the second intermediate and a fluorinating reagent, quenching, and carrying out diazotization reaction on the second intermediate and a sodium nitrite aqueous solution to obtain diazonium salt; step 4, carrying out high-temperature cracking on the diazonium salt, to obtain 2,4,5-trifluorotoluene; and step 5 to step 7, carrying out halogenation, cyanidation and hydrolysis reactions on 2,4,5-trifluorotoluene in sequence, and thus obtaining 2,4,5-trifluorophenylacetic acid. The raw materials adopted by the method are easy to obtain and low in cost, the yield of the corresponding product obtained in each step is high, and large-scale production of the 2,4,5-trifluorophenylacetic acid is facilitated.

Electrophilic aromatic fluorination with fluorine: meta-Directed fluorination of anilines

Anilines are mainly or selectively fluorinated in the meta-position with F2 when dissolved in triflic acid, sometimes in the presence of small quantities of antimony pentafluoride. The regioselectivity is increased when an electron-donating substituent is present at the para-position.