88124-55-4

Basic information

• Product Name: ethyl (5-amino-1,3,4-thiadiazol-2-yl)acetate(SALTDATA: FREE)
• Synonyms: ethyl (5-amino-1,3,4-thiadiazol-2-yl)acetate(SALTDATA: FREE);Ethyl (5-amino-1,3,4-thiadiazol-2-yl)acetate;1,3,4-Thiadiazole-2-acetic acid, 5-amino-, ethyl ester
• CAS NO: 88124-55-4
• Molecular Formula: C₆H₉N₃O₂S
• Molecular Weight: 187.21956
• Mol File: 88124-55-4.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 343.6°C at 760 mmHg
• Flash Point: 161.6°C
• Appearance: /
• Density: 1.367g/cm³
• Vapor Pressure: 6.96E-05mmHg at 25°C
• Refractive Index: 1.581
• CAS DataBase Reference: ethyl (5-amino-1,3,4-thiadiazol-2-yl)acetate(SALTDATA: FREE)(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl (5-amino-1,3,4-thiadiazol-2-yl)acetate(SALTDATA: FREE)(88124-55-4)
• EPA Substance Registry System: ethyl (5-amino-1,3,4-thiadiazol-2-yl)acetate(SALTDATA: FREE)(88124-55-4)

Safety Data

• Hazardous Substances Data: 88124-55-4(Hazardous Substances Data)

Usage

General Description

Ethyl (5-amino-1,3,4-thiadiazol-2-yl)acetate is a chemical compound with the molecular formula C6H8N2O2S. It is commonly known as SALTDATA: FREE and is used in various pharmaceutical and chemical research applications. ethyl (5-amino-1,3,4-thiadiazol-2-yl)acetate(SALTDATA: FREE) is a derivative of 1,3,4-thiadiazole and is known for its potential biological and pharmacological activities. Ethyl (5-amino-1,3,4-thiadiazol-2-yl)acetate has been studied for its anti-inflammatory, analgesic, and anticonvulsant properties, making it an important compound in the development of new drugs and therapies. Its unique chemical structure and properties make it an important target for further research and exploration in the pharmaceutical industry.

InChI:InChI=1/C6H9N3O2S/c1-2-11-5(10)3-4-8-9-6(7)12-4/h2-3H2,1H3,(H2,7,9)

Upstream product

• 34570-16-6 ethyl malonic monoimidate hydrochloride 
• 79-19-6 thiosemicarbazide 
• 2318-25-4 ethyl 3-ethoxy-3-iminopropanoate hydrochloride 
• 36239-09-5 ethyl chlorocarbonylacetate 

Downstream Products

• 1191951-70-8 ethyl 2-(5-(4-decanamidophenylsulfonamido)-1,3,4-thiadiazol-2-yl)acetate 
• 1191951-68-4 ethyl 2-(5-(4-acetamidophenylsulfonamido)-1,3,4-thiadiazol-2-yl)acetate 
• 1191951-62-8 ethyl 2-(5-(4-dodecylphenylsulfonamido)-1,3,4-thiadiazol-2-yl)acetate 
• 128639-53-2 (5-Amino-[1,3,4]thiadiazol-2-yl)-(phenyl-hydrazono)-acetic acid ethyl ester 
• 128639-54-3 (5-Amino-[1,3,4]thiadiazol-2-yl)-(p-tolyl-hydrazono)-acetic acid ethyl ester 
• 118863-94-8 (amino-[1,3,4]thiadiazol-2-yl)-acetic acid 

Relevant articles and documents

Development of sulfonamide AKT PH domain inhibitors

Disruption of the phosphatidylinositol 3-kinase/AKT signaling pathway can lead to apoptosis in cancer cells. Previously we identified a lead sulfonamide that selectively bound to the pleckstrin homology (PH) domain of AKT and induced apoptosis when present at low micromolar concentrations. To examine the effects of structural modification, a set of sulfonamides related to the lead compound was designed, synthesized, and tested for binding to the expressed PH domain of AKT using a surface plasmon resonance-based competitive binding assay. Cellular activity was determined by means of an assay for pAKT production and a cell killing assay using BxPC-3 cells. The most active compounds in the set are lipophilic and possess an aliphatic chain of the proper length. Results were interpreted with the aid of computational modeling. This paper represents the first structure-activity relationship (SAR) study of a large family of AKT PH domain inhibitors. Information obtained will be used in the design of the next generation of inhibitors of AKT PH domain function.

STUDIES ON ALKYLHETEROAROMATIC COMPOUNDS: NEW SYNTHESES OF 1,3,4-OXADIAZOLE, OXADIAZOLOPYRIDINE, 1,3,4-THIADIAZOLE, THIADIAZOLOPYRIDINE, PHTHALAZINE AND THIENOPYRIDAZINE DERIVATIVES.

Ethyl 5-phenyl-1,3,4-oxadiazol-2-ylacetate (3a) could be prepared via condensation of ethyl 3-amino-3-ethoxyprop-2-enoate (1) with benzoylhydrazine.This product coupled with aromatic diazonium salts to yield arylhydrazones 4a,b.Compound 3a was converted i