88214-56-6

Basic information

• Product Name: trans-4-chloro-2-phenyl-3,4-dihydro-2H-chromene
• CAS NO: 88214-56-6
• Molecular Weight: 244.721
• Mol File: 88214-56-6.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: trans-4-chloro-2-phenyl-3,4-dihydro-2H-chromene(CAS DataBase Reference)
• NIST Chemistry Reference: trans-4-chloro-2-phenyl-3,4-dihydro-2H-chromene(88214-56-6)
• EPA Substance Registry System: trans-4-chloro-2-phenyl-3,4-dihydro-2H-chromene(88214-56-6)

Safety Data

• Hazardous Substances Data: 88214-56-6(Hazardous Substances Data)

Upstream product

• 100-52-7 benzaldehyde 
• 118-93-4 o-hydroxyacetophenone 
• 487-26-3 Flavanone 
• 58253-89-7 trans-4-bromoflavan 
• 487-25-2 cis-4-hydroxyflavan 
• 487-25-2 2',4-dihydroxydihydrochalcone 

Downstream Products

• 31696-64-7 (2R,4R)-2-Phenyl-4-p-tolyloxy-chroman 
• 88214-64-6 Phenyl-((2R,4R)-2-phenyl-chroman-4-yl)-amine 
• 88214-64-6 Phenyl-((2S,4R)-2-phenyl-chroman-4-yl)-amine 
• 6517-13-1 cis-4-acetamidoflavan 
• 93514-42-2 2-phenylchromene 
• 88214-65-7 N-flavan-4β-ylglycine ethyl ester 
• 88214-65-7 N-flavan-4α-ylglycine ethyl ester 
• 88214-63-5 N-flavan-4β-ylbenzylamine 
• 6833-55-2 cis-4-phthalimidoflavan 
• 104819-73-0 trans-flavan-4-ol tosylate 
• 58253-89-7 trans-4-bromoflavan 
• 6517-13-1 trans-4-acetamidoflavan 
• 31696-63-6 (2R,4R)-4-Phenoxy-2-phenyl-chroman 
• 487-25-2 2',4-dihydroxydihydrochalcone 

Relevant articles and documents

Synthesis, enantiomeric separation and docking studies of spiropiperidine analogues as ligands of the nociceptin/orphanin FQ receptor

A series of triazospirodecanone derivatives were synthesized as potential NOP ligands. 8-(Chroman-4-yl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one (4) and its 5-fluoro analogue (18) proved to be active as agonists with EC50 values in the submicromolar range. Single enantiomers of compound 4 were separated and tested as NOP agonists; the eutomer R-(+)-4 showed a pEC 50 of 7.34. Finally docking studies were performed on the NOP receptor to identify the most significant stereospecific interactions.

Synthesis of 4-Substituted Flavans from 4α-Halogenoflavans

The reactions of flavan-4α- or -4β-ols unsubstituted in ring A with phosphorus or similar halides give 4α-halogenoflavans which react with a variety of nucleophiles (phenolate ions, thiophenolate ions, amines, and alcohols) yielding the corresponding 4-su