88229-28-1

Basic information

• Product Name: Benzamide, 4-methyl-N,N-bis(phenylmethyl)-
• CAS NO: 88229-28-1
• Molecular Formula: C22H21NO
• Molecular Weight: 315.415
• Mol File: 88229-28-1.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: Benzamide, 4-methyl-N,N-bis(phenylmethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzamide, 4-methyl-N,N-bis(phenylmethyl)-(88229-28-1)
• EPA Substance Registry System: Benzamide, 4-methyl-N,N-bis(phenylmethyl)-(88229-28-1)

Safety Data

• Hazardous Substances Data: 88229-28-1(Hazardous Substances Data)

Upstream product

• 201230-82-2 carbon monoxide 
• 780-25-6 N-benzylidene benzylamine 
• 106-45-6 para-thiocresol 
• 874-60-2 4-methyl-benzoyl chloride 
• 103-49-1 dibenzylamine 
• 100-52-7 benzaldehyde 
• 100-46-9 benzylamine 
• 17761-41-0 N-chloro-N-(phenylmethyl)-benzenemethanamine 
• 104-87-0 4-methyl-benzaldehyde 
• 80326-96-1 ethyl 2-(dibenzylamino)-2-oxoacetate 
• 624-31-7 4-tolyl iodide 
• 52742-32-2 N,N-dibenzyl-O-benzoylhydroxylamine 
• 98-88-4 benzoyl chloride 
• 1485-70-7 N-benzylbenzamide 

Downstream Products

• 1618673-01-0 dimethyl 2-((N,N-dibenzylamino)(p-tolyl)methylene)malonate 
• 891414-34-9 N,N-dibenzyl-N-(4-methylbenzyl)amine 
• 104-85-8 para-methylbenzonitrile 
• 5436-83-9 N-benzyl-4-methylbenzamide 
• 2001-28-7 2-phenyl-1-p-tolyl-ethanone 

Relevant articles and documents

Synthesis method of aromatic amide compound

The invention discloses a synthesis method of an aromatic amide compound, and belongs to the technical field of chemical synthesis. The synthesis method comprises the following steps: reacting an aldehyde compound, an O-benzoyl hydroxylamine compound and peroxide in an atmosphere for 6-10 h; and sequentially filtering, washing, drying and carrying out column chromatography separation and purification on the reaction solution after the reaction is finished to obtain the aromatic amide product. The method is direct, simple and efficient, the substrate universality is good, and the obtained aromatic amide compound has great applications in the fields of medicines, pesticides and high polymer materials.

Room-Temperature Decarboxylative Couplings of α-Oxocarboxylates with Aryl Halides by Merging Photoredox with Palladium Catalysis

Enabled by merging iridium photoredox catalysis and palladium catalysis, α-oxocarboxylate salts can be decarboxylatively coupled with aryl halides to generate aromatic ketones and amides at room temperature. DFT calculations suggest that this reaction proceeds through a Pd0-PdII-PdIII pathway, in which the PdIII intermediate is responsible for reoxidizing IrII to complete the IrIII-IrIII-IrII photoredox cycle. Like a mergin': Enabled by merging iridium photoredox catalysis and palladium catalysis, palladium-catalyzed decarboxylative coupling of α-oxocarboxylates with aryl halides can proceed at room temperature. DFT calculations suggest that a Pd0-PdII-PdIII catalytic cycle is merged with an IrIII-IrIII-IrII photoredox cycle, in which PdIII is responsible for oxidizing IrII to complete the photoredox cycle.

A convenient and general iron-catalyzed reduction of amides to amines

While the iron is hot: The first general and efficient iron-catalyzed reduction of secondary and tertiary amides into amines using polymethylhydrosiloxane (PMHS) has been developed (see scheme).