883195-08-2

Basic information

• Product Name: Cyclohexanamine, 4-(4-methyl-1-piperazinyl)-, trans-
• CAS NO: 883195-08-2
• Molecular Formula: C11H23N3
• Molecular Weight: 197.324
• Mol File: 883195-08-2.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: Cyclohexanamine, 4-(4-methyl-1-piperazinyl)-, trans-(CAS DataBase Reference)
• NIST Chemistry Reference: Cyclohexanamine, 4-(4-methyl-1-piperazinyl)-, trans-(883195-08-2)
• EPA Substance Registry System: Cyclohexanamine, 4-(4-methyl-1-piperazinyl)-, trans-(883195-08-2)

Safety Data

• Hazardous Substances Data: 883195-08-2(Hazardous Substances Data)

Usage

Description

Cyclohexanamine, 4-(4-methyl-1-piperazinyl)-, transis a chemical compound that belongs to the class of cyclohexylamines. It is a trans-isomer of 4-(4-methyl-1-piperazinyl)cyclohexanamine, characterized by its unique molecular structure and versatile pharmacological properties.

Uses

Used in Pharmaceutical Industry:
Cyclohexanamine, 4-(4-methyl-1-piperazinyl)-, transis used as a medication for treating various mental disorders such as depression and anxiety. It functions as a selective serotonin reuptake inhibitor (SSRI), increasing serotonin levels in the brain by blocking its reabsorption by neurons, thereby improving mood, reducing anxiety, and alleviating other symptoms of mental illness.
Used in Neurotransmitter Research:
As a potential ligand for various neurotransmitter receptors, Cyclohexanamine, 4-(4-methyl-1-piperazinyl)-, transis utilized in research and development for its therapeutic potential in modulating neurotransmission and exploring novel treatment options for neurological and psychiatric conditions.

Upstream product

• 27514-08-5 N-(4-oxocyclohexyl)acetamide 
• 109-01-3 1-methyl-piperazine 
• 1119283-62-3 (trans)-N,N-dibenzyl-4-(4-methylpiperazin-1-yl)cyclohexanamine 
• 149506-79-6 4-(dibenzylamino)cyclohexanone 
• 50910-54-8 trans-4-aminocyclohexanol hydrochloride 
• 149506-81-0 trans-4-(dibenzylamino)cyclohexanol 

Downstream Products

• 1280665-07-7 7-[[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-7H-pteridin-2-yl]amino]-N-[(trans)-4-(4-methylpiperazin-1-yl)cyclohexyl]-2,3-dihydrobenzofuran-4-carboxamide 
• 1280665-04-4 7-[[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-7H-pteridin-2-yl]amino]-2,2-dimethyl-N-[(trans)-4-(4-methylpiperazin-1-yl)cyclohexyl]-3H-benzofuran-4-carboxamide 

Relevant articles and documents

PROCESS FOR THE PREPARATION OF A PYRIMIDINO-DIAZEPINE DERIVATIVE

In one aspect, the invention relates to a process for preparing a compound of formula (XII), wherein PG is a protecting group, or a compound of formula (XI), comprising the steps of: (i) treating a compound of formula XIII, wherein PG is a protecting group, with N- methylpiperazine to form a compound of formula XII, wherein said compound of formula XII is in the form of a mixture of cis and trans isomers; (ii) combining the mixture formed in step (i) with an organic solvent and heating the solvent mixture so formed; (iii) isolating the trans-isomer of the compound of formula XII from the solvent mixture formed in step (ii); and (iv) optionally treating said trans-isomer of the compound of formula XII with an acid to form a compound of formula XI; and isolating said compound of formula XI. Further aspects of the invention relate to processes for preparing pyrimido-diazepinone derivatives using the above process and intermediates.

DIHYDROPTERIDINONE DERIVATIVES, PREPARATION PROCESS AND PHARMACEUTICAL USE THEREOF

Dihydroperidinone derivatives, preparation process and pharmaceutical use thereof are disclosed. Specially, new dihydroperidinone derivatives represented by general formula (I), wherein each substituent of the general formula (I) is defined as in the description, their preparation process, pharmaceutical compositions comprising said derivatives and their use as therapeutical agents, especially as Plk kinase inhibitors are disclosed.

NEW COMPOUNDS

Novel compounds of which the following is exemplary: